LAUSR: molecular mechanism

Recurrent seizure‐related GRIN1 variant: Molecular mechanism and targeted therapy

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0 Published in 2021 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51406

Abstract: Genetic variants in the GRIN genes that encode N‐methyl‐D‐aspartate receptor (NMDAR) subunits have been identified in various neurodevelopmental disorders, including epilepsy. We identified a GRIN1 variant from an individual with early‐onset epileptic encephalopathy, evaluated functional… read more here.

Keywords: related grin1; recurrent seizure; variant molecular; seizure related ... See more keywords

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The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues

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0 Published in 2020 at "Cancer Medicine"

DOI: 10.1002/cam4.3434

Abstract: Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide and tends to be detected at an advanced stage. More effective biomarkers for HCC screening and prognosis assessment are needed and the mechanisms of… read more here.

Keywords: hepatocellular carcinoma; carcinoma; clinical value; value potential ... See more keywords

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In vivo immunotoxicity of Gd2O3:Eu3+ nanoparticles and the associated molecular mechanism

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0 Published in 2020 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.22562

Abstract: The in vivo toxicity of Gd2O3:Eu3+ nanoparticles (NPs) used as dual‐modal nanoprobes for molecular imaging has not been studied, and the corresponding molecular mechanism of immunotoxicity remains unknown. In this study, we investigated the cytotoxicity,… read more here.

Keywords: immunotoxicity; gd2o3 eu3; molecular mechanism; vivo ... See more keywords

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Molecular mechanism of Notch signaling with special emphasis on microRNAs: Implications for glioma

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0 Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26775

Abstract: Glioma is the most aggressive primary brain tumor and is notorious for resistance to chemoradiotherapy. Although its associated mechanisms are still not completely understood, Notch signaling, an evolutionarily conserved pathway, appears to be the key… read more here.

Keywords: mechanism notch; glioma; signaling special; molecular mechanism ... See more keywords

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Molecular mechanism of high-production tannase of Aspergillus carbonarius NCUF M8 after ARTP mutagenesis: revealed by RNA-seq and molecular docking.

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1 Published in 2022 at "Journal of the science of food and agriculture"

DOI: 10.1002/jsfa.11754

Abstract: BACKGROUND Tannase is an enzyme produced by microbial fermentation that is widely used in the food industry; however, the molecular mechanism of tannase production by Aspergillus has not yet been studied. This study was conducted… read more here.

Keywords: tannase; aspergillus carbonarius; production; high production ... See more keywords

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Molecular mechanism of anti‐adipogenic effect of vitexin in differentiating hMSCs

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0 Published in 2021 at "Phytotherapy Research"

DOI: 10.1002/ptr.7300

Abstract: In this study, we evaluated a detailed molecular mechanism of anti‐adipogenic activity of vitexin, apigenin flavone glucoside, present in germinated fenugreek seeds, in differentiating human mesenchymal stem cells (hMSCs). The lipid content of differentiated adipocytes… read more here.

Keywords: vitexin; anti adipogenic; mechanism anti; effect ... See more keywords

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Molecular Mechanism of Plant Recognition of Extracellular ATP.

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0 Published in 2017 at "Advances in experimental medicine and biology"

DOI: 10.1007/5584_2017_110

Abstract: Adenosine 5'-triphosphate (ATP), a ubiquitously dispersed biomolecule, is not only a major source of biochemical energy for living cells, but also acts as a critical signaling molecule through inter-cellular communication. Recent studies have clearly shown… read more here.

Keywords: atp; plant recognition; extracellular atp; mechanism plant ... See more keywords

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Elucidation of the molecular mechanism underlying the anti-inflammatory activity of an effective and safe bipyrazole-based compound

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0 Published in 2019 at "Inflammation Research"

DOI: 10.1007/s00011-019-01225-z

Abstract: IntroductionSince the synthesis of acetylsalicylic acid by Hoffmann in 1897, new classes of NSAIDs have been introduced; however, their side effects have limited their clinical applications. Consequently, our team has recently synthesized a novel bipyrazole… read more here.

Keywords: anti inflammatory; bipyrazole; bipyrazole compound; compound ... See more keywords

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Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC

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0 Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03386-w

Abstract: An intrinsically disordered neuronal protein α-synuclein (αSyn) is known to cause mitochondrial dysfunction, contributing to loss of dopaminergic neurons in Parkinson’s disease. Through yet poorly defined mechanisms, αSyn crosses mitochondrial outer membrane and targets respiratory… read more here.

Keywords: vdac; mechanism olesoxime; translocation; syn translocation ... See more keywords

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Changes in the physiological characteristics of Panax ginseng embryogenic calli and molecular mechanism of ginsenoside biosynthesis under cold stress.

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0 Published in 2021 at "Planta"

DOI: 10.1007/s00425-020-03535-7

Abstract: MAIN CONCLUSION Short-term cold stress can induce the increased expression of key enzyme-encoding genes involved in secondary metabolite synthesis, thereby increasing secondary metabolite concentration. Cold stress is an ecologically limiting factor that strongly affects the… read more here.

Keywords: ginseng; calli; stress; molecular mechanism ... See more keywords