Controlling contacts—Molecular mechanisms to regulate organelle membrane tethering
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200151
Abstract: In recent years, membrane contact sites (MCS), which mediate interactions between virtually all subcellular organelles, have been extensively characterized and shown to be essential for intracellular communication. In this review essay, we focus on an… read more here.
Keywords: regulate organelle; molecular mechanisms; mechanisms regulate; contacts molecular ... See more keywords
Distinct molecular mechanisms control levels of synaptic F‐actin
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11226
Abstract: Polymerization of filamentous (F)‐actin at the neuronal synapse plays an important role in neuronal function. However, the regulatory mechanisms controlling the levels of synaptic actin remain incompletely understood. Here, I used established pharmacological blockers to… read more here.
Keywords: actin; distinct molecular; synaptic actin; levels synaptic ... See more keywords
Structural States of RORγt: X‐ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700278
Abstract: The T‐cell‐specific retinoic acid receptor (RAR)‐related orphan receptor‐γ (RORγt) is a key transcription factor for the production of pro‐inflammatory Th17 cytokines, which are implicated in the pathogenesis of autoimmune diseases. Over the years, several structurally… read more here.
Keywords: natural synthetic; synthetic compounds; inverse agonists; structural states ... See more keywords
Ocular dominance plasticity: Molecular mechanisms revisited
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25001
Abstract: Ocular dominance plasticity (ODP) is a type of cortical plasticity operating in visual cortex of mammals that are endowed with binocular vision based on the competition‐driven disparity. Earlier, a molecular mechanism was proposed that catecholamines… read more here.
Keywords: dominance plasticity; plasticity molecular; molecular mechanisms; ocular dominance ... See more keywords
Examining the molecular mechanisms contributing to the success of an invasive species across different ecosystems
Sign Up to like & getrecommendations! Published in 2020 at "Ecology and Evolution"
DOI: 10.1002/ece3.6688
Abstract: Abstract Invasive species provide an opportune system to investigate how populations respond to new environments. Baby's breath (Gypsophila paniculata) was introduced to North America in the 1800s and has since spread throughout the United States… read more here.
Keywords: success invasive; invasive species; success; molecular mechanisms ... See more keywords
Mechanosensitive molecular mechanisms of myocardial fibrosis in living myocardial slices
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13832
Abstract: Altered mechanical load in response to injury is a main driver of myocardial interstitial fibrosis. No current in vitro model can precisely modulate mechanical load in a multicellular environment while maintaining physiological behaviour. Living myocardial… read more here.
Keywords: myocardial slices; myocardial fibrosis; molecular mechanisms; mechanosensitive molecular ... See more keywords
Molecular mechanisms within the dentate gyrus and the perirhinal cortex interact during discrimination of similar nonspatial memories
Sign Up to like & getrecommendations! Published in 2020 at "Hippocampus"
DOI: 10.1002/hipo.23269
Abstract: Differentiating between similar memories is a crucial cognitive function that enables correct episodic memory formation. The ability to separate the components of memories into distinct representations is thought to rely on a computational process known… read more here.
Keywords: molecular mechanisms; dentate gyrus; memory; pattern separation ... See more keywords
MOLECULAR MECHANISMS AND COMBINATION STRATEGIES WITH PI3K AND BTK INHIBITORS TO OVERCOME INTRINSIC AND ACQUIRED RESISTANCE IN PRECLINICAL MODELS OF ABC‐DLBCL
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_179
Abstract: The Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has demonstrated promising efficacy in a variety of hematologic malignancies. However, the precise mechanism of action of the drug remains to be fully elucidated. Tumor‐infiltrating macrophages presented in… read more here.
Keywords: inhibitor; mechanisms combination; combination strategies; btk inhibitor ... See more keywords
Predicting pathogenicity of missense variants with weakly supervised regression
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23826
Abstract: Quickly growing genetic variation data of unknown clinical significance demand computational methods that can reliably predict clinical phenotypes and deeply unravel molecular mechanisms. On the platform enabled by the Critical Assessment of Genome Interpretation (CAGI),… read more here.
Keywords: supervised regression; regression; weakly supervised; pathogenicity ... See more keywords
Cytogenetically visible inversions are formed by multiple molecular mechanisms
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DOI: 10.1002/humu.24106
Abstract: Cytogenetically detected inversions are generally assumed to be copy number and phenotypically neutral events. While nonallelic homologous recombination is thought to play a major role, recent data suggest the involvement of other molecular mechanisms in… read more here.
Keywords: copy number; visible inversions; molecular mechanisms; cytogenetically visible ... See more keywords
Molecular mechanisms of oxidative stress-related neonatal jaundice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23349
Abstract: Oxidative stress is a pathological condition characterized by an overload of oxidant products, named free radicals, which are not well counteracted by antioxidant systems. Free radicals induce oxidative damage to many body organs and systems.… read more here.
Keywords: stress; stress related; molecular mechanisms; oxidative stress ... See more keywords