Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2019.12.015
Abstract: Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in… read more here.
Keywords: deep multilayer; alzheimer disease; molecular networks; progression ... See more keywords
Molecular networks orchestrating plant cell growth.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2016.11.010
Abstract: Plant cell growth can broadly be categorized into either diffuse or tip growth. Here we compare gene regulatory networks (GRNs) controlling growth of hypocotyls and root hairs as examples for diffuse and tip growth, respectively.… read more here.
Keywords: cell; cell growth; molecular networks; growth ... See more keywords
Energy Dissipation from Confined States in Nanoporous Molecular Networks.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c05333
Abstract: Crystalline nanoporous molecular networks are assembled on the Ag(111) surface, where the pores confine electrons originating from the surface state of the metal. Depending on the pore sizes and their coupling, an antibonding level is… read more here.
Keywords: energy dissipation; dissipation; molecular networks; confined states ... See more keywords
Robustness and lethality in multilayer biological molecular networks
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19841-3
Abstract: Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and… read more here.
Keywords: robustness lethality; multilayer biological; layer; lethality multilayer ... See more keywords
Improving annotation propagation on molecular networks through random walks: introducing ChemWalker
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad078
Abstract: Annotation of the mass signals is still the biggest bottleneck for the untargeted mass spectrometry analysis of complex mixtures. Molecular networks are being increasingly adopted by the mass spectrometry community as a tool to annotate… read more here.
Keywords: annotation propagation; random walks; chemwalker; molecular networks ... See more keywords
A novel high throughput screen to identify candidate molecular networks that regulate spermatogenic stem cell functions
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac048
Abstract: Abstract Spermatogenic regeneration is key for male fertility and relies on activities of an undifferentiated spermatogonial population. Here, a high-throughput approach with primary cultures of mouse spermatogonia was devised to rapidly predict alterations in functional… read more here.
Keywords: cell; throughput; high throughput; molecular networks ... See more keywords
Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079475.122
Abstract: The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation. This review… read more here.
Keywords: ribonuclease; gene targeting; rnase; molecular networks ... See more keywords
Changing Paradigm of Biochemical Sciences:Molecular Networks in Health and Disease
Sign Up to like & getrecommendations! Published in 2017 at "Current Science"
DOI: 10.18520/cs/v112/i02/219-219
Abstract: The 23rd meeting of TRendys in Biochemistry was held recently. TRendys is a national forum to discuss frontier areas and concepts in biochemistry. The meeting was inaugurated by S. K. Srivastava (North-Eastern Hill University (NEHU),… read more here.
Keywords: biochemistry; biochemical sciences; paradigm biochemical; sciences molecular ... See more keywords
Analyzing of Molecular Networks for Human Diseases and Drug Discovery
Sign Up to like & getrecommendations! Published in 2018 at "Current Topics in Medicinal Chemistry"
DOI: 10.2174/1568026618666180813143408
Abstract: Molecular networks represent the interactions and relations of genes/proteins, and also encode molecular mechanisms of biological processes, development and diseases. Among the molecular networks, protein-protein Interaction Networks (PINs) have become effective platforms for uncovering the… read more here.
Keywords: diseases drug; analyzing molecular; drug; drug discovery ... See more keywords
In silico investigation of molecular networks linking gastrointestinal diseases, malnutrition, and sarcopenia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.989453
Abstract: Malnutrition is a common primary or secondary complication in gastrointestinal diseases. The patient’s nutritional status also influences muscle mass and function, which can be impaired up to the degree of sarcopenia. The molecular interactions in… read more here.
Keywords: gastrointestinal diseases; silico investigation; malnutrition; investigation molecular ... See more keywords
A Detailed Catalogue of Multi-Omics Methodologies for Identification of Putative Biomarkers and Causal Molecular Networks in Translational Cancer Research
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22062822
Abstract: Recent advances in sequencing and biotechnological methodologies have led to the generation of large volumes of molecular data of different omics layers, such as genomics, transcriptomics, proteomics and metabolomics. Integration of these data with clinical… read more here.
Keywords: multi omics; cancer; causal molecular; molecular networks ... See more keywords