Molecular pathophysiology of human MICU1 deficiency
Sign Up to like & getrecommendations! Published in 2021 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12694
Abstract: MICU1 encodes the gatekeeper of the mitochondrial Ca2+ uniporter, MICU1 and biallelic loss‐of‐function mutations cause a complex, neuromuscular disorder in children. Although the role of the protein is well understood, the precise molecular pathophysiology leading… read more here.
Keywords: molecular pathophysiology; micu1 deficiency; pathophysiology; human micu1 ... See more keywords
The Molecular Pathophysiology of Psoriatic Arthritis—The Complex Interplay Between Genetic Predisposition, Epigenetics Factors, and the Microbiome
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.662047
Abstract: Psoriasis is a symmetric autoimmune/inflammatory disease that primarily affects the skin. In a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the spine, and/or include enthesitis. Psoriasis and psoriatic… read more here.
Keywords: psoriatic arthritis; molecular pathophysiology; complex interplay; psoriasis ... See more keywords
COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113260
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated type 1 interferon (IFN-1) production, the pathophysiology of which involves sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) tetramerization and the cytosolic DNA sensor cyclic-GMP-AMP… read more here.
Keywords: acetylation; acetylation repurposing; pathophysiology; covid molecular ... See more keywords