Genetic basis of sleep phenotypes and rare neurodevelopmental syndromes reveal shared molecular pathways
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25180
Abstract: Sleep‐related phenotypes have been frequently reported in early on‐set epileptic encephalopathies and in developmental delay syndromes, in particular in syndromes related to autism spectrum disorder. Yet the convergent pathogenetic mechanisms between these comorbidities are largely… read more here.
Keywords: neurodevelopmental disorders; developmental delay; epileptic encephalopathies; molecular pathways ... See more keywords
The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04337-8
Abstract: Doxorubicin (DOX) is an effective chemotherapy agent against a wide variety of tumors. However, intrinsic or acquired resistance diminishes the sensitivity of cancer cells to DOX, which leads to a cancer relapse and treatment failure.… read more here.
Keywords: dox sensitivity; sensitivity; resistance; cancer ... See more keywords
Molecular pathways involved in lymphedema: hydroxytyrosol as a candidate natural compound for treating the symptoms caused by lymph accumulation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.11.017
Abstract: Lymphedema is a chronic accumulation of interstitial fluid due to inefficient lymph drainage. Major causes of lymphedema are malformations of lymphatic vessels, trauma, toxic damage and surgery. The swelling typically affects the limbs. Lymphedema may… read more here.
Keywords: accumulation; hydroxytyrosol; compound; pathways involved ... See more keywords
Targeting molecular pathways in cancer stem cells by natural bioactive compounds
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.08.006
Abstract: ABSTRACT Cancer Stem Cells (CSCs) or Tumor‐Initiating Cells (TICs) are a small sub‐population of cells within the tumor, able to give chemio‐ and radio‐resistance and cause the onset of metastasis and the presence of relapses;… read more here.
Keywords: cancer stem; natural bioactive; bioactive compounds; molecular pathways ... See more keywords
Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Medicine"
DOI: 10.1080/07853890.2020.1814962
Abstract: Abstract The development of effective combined anti-retroviral therapy (cART) led to a significant reduction in the death rate associated with human immunodeficiency virus type 1 (HIV-1) infection. However, recent studies indicate that considerably more than… read more here.
Keywords: hiv; hand; role; molecular pathways ... See more keywords
Data aggregation at the level of molecular pathways improves stability of experimental transcriptomic and proteomic data
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1361068
Abstract: ABSTRACT High throughput technologies opened a new era in biomedicine by enabling massive analysis of gene expression at both RNA and protein levels. Unfortunately, expression data obtained in different experiments are often poorly compatible, even… read more here.
Keywords: aggregation level; pathways improves; data aggregation; level molecular ... See more keywords
Risk of lung adenocarcinoma from smoking and radiation arises in distinct molecular pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz036
Abstract: KRAS mutations of lung adenocarcinoma (LADC) are associated with smoking but little is known on other exposure-oncogene associations. Hypothesizing that different inciting agents may cause different driver mutations, we aimed to identify distinct molecular pathways… read more here.
Keywords: lung adenocarcinoma; risk; exposure; distinct molecular ... See more keywords
Analysis of exome data in a UK cohort of 603 patients with syndromic orofacial clefting identifies causal molecular pathways
Sign Up to like & getrecommendations! Published in 2023 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddad023
Abstract: Abstract Orofacial cleft (OC) is a common congenital anomaly in humans, which has lifelong implications for affected individuals. This disorder can be classified as syndromic or non-syndromic depending on the presence or absence of additional… read more here.
Keywords: syndromic orofacial; non syndromic; orofacial clefting; molecular pathways ... See more keywords
Molecular pathways dysregulated by Pb2+ exposure prompts pancreatic beta-cell dysfunction.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfab121
Abstract: Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by reduced insulin sensitivity and dysfunction of β-cells. Although the increasing prevalence of diabetes worldwide is largely attributed to genetic predisposition or lifestyle factors (insufficient… read more here.
Keywords: cell; pb2 exposure; dysfunction; pathways dysregulated ... See more keywords
Conserved molecular pathways underlying biting in two divergent mosquito genera
Sign Up to like & getrecommendations! Published in 2022 at "Evolutionary Applications"
DOI: 10.1111/eva.13379
Abstract: Mosquitoes transmit a wide variety of devastating pathogens when they bite vertebrate hosts and feed on their blood. However, three entire mosquito genera and many individual species in other genera have evolved a nonbiting life… read more here.
Keywords: biting nonbiting; culex; molecular pathways; life history ... See more keywords
Molecular pathways regulated by areca nut in the etiopathogenesis of oral submucous fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Periodontology 2000"
DOI: 10.1111/prd.12266
Abstract: Many oral mucosal lesions are due to substance abuse, such as tobacco and areca nut, amongst others. There is considerable evidence that oral lesions/disorders such as some leukoplakias, most erythroplakias, and submucous fibrosis have malignant… read more here.
Keywords: areca nut; pathways regulated; fibrosis; submucous fibrosis ... See more keywords