Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.08.018
Abstract: We have recently reported that a short course of morphine, starting 10days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization… read more here.
Keywords: associated molecular; morphine; nlrp3 inflammasomes; molecular patterns ... See more keywords
DANGER SIGNALS IN LIVER INJURY AND RESTORATION OF HOMEOSTASIS.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.04.033
Abstract: Damage-associated molecular patterns are signaling molecules involved in inflammatory responses and restoration of homeostasis. Chronic release of these molecules can also promote inflammation, including in the context of liver disease. This comprehensive summary describes the… read more here.
Keywords: associated molecular; liver; molecular patterns; damage associated ... See more keywords
Six molecular patterns leading to hemophilia A phenotype in 18 females from Poland.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/j.thromres.2020.05.041
Abstract: INTRODUCTION Female hemophilia is an intriguing rare disorder and few larger reports on its genetic etiology are available. While historically the diagnosis was satisfactorily reached by factor VIII activity assays, the clinical and potentially therapeutic… read more here.
Keywords: female hemophilia; hemophilia phenotype; etiology; six molecular ... See more keywords
Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-025-01354-y
Abstract: The inflammasome is an inflammatory signaling protein complex comprising a sensor protein, the adaptor protein ASC, and the cysteine protease caspase-1. Inflammasome sensor proteins are activated by microbial molecular patterns, endogenous self-derived damage signals, or… read more here.
Keywords: molecular patterns; inflammasome activation; damage; molecular mechanisms ... See more keywords
Synthetic mycobacterial molecular patterns partially complete Freund’s adjuvant
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62543-5
Abstract: Complete Freund’s adjuvant (CFA) has historically been one of the most useful tools of immunologists. Essentially comprised of dead mycobacteria and mineral oil, we asked ourselves what is special about the mycobacterial part of this… read more here.
Keywords: molecular patterns; complete freund; freund adjuvant; synthetic mycobacterial ... See more keywords
Damage-associated molecular patterns and their role as initiators of inflammatory and auto-immune signals in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "International Reviews of Immunology"
DOI: 10.1080/08830185.2017.1365146
Abstract: ABSTRACT Damage-associated molecular patterns (DAMPs) are endogenous molecules that are released into the extracellular space under conditions of activation, cellular stress, or tissue damage. These molecules are recognized by pattern-recognition receptors (PRRs) and can induce… read more here.
Keywords: auto; associated molecular; molecular patterns; auto immune ... See more keywords
Linear β-1,2-glucans trigger immune hallmarks and enhance disease resistance in plants
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erae368
Abstract: Abstract Immune responses in plants are triggered by molecular patterns or elicitors, recognized by plant pattern recognition receptors. Such molecular patterns are the consequence of host–pathogen interactions, and the response cascade activated after their perception… read more here.
Keywords: molecular patterns; linear glucans; hallmarks enhance; trigger immune ... See more keywords
Danger Signals in the ICU
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003007
Abstract: Objectives: Sterile and infectious critical illnesses often result in vasoplegic shock and a robust systemic inflammatory response that are similar in presentation. The innate immune system is at the center of the response to both… read more here.
Keywords: associated molecular; response; molecular patterns; damage associated ... See more keywords
Regulatory T cells, damage-associated molecular patterns, and myeloid-derived suppressor cells in bronchoalveolar lavage fluid interlinked with chronic obstructive pulmonary disease severity
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029208
Abstract: Abstract The role of regulatory T cells (Tregs), damage-associated molecular patterns (DAMPs), and myeloid-derived suppressor cells (MDSCs) in the mechanism of innate and adaptive immune responses in chronic obstructive pulmonary disease (COPD) is not well… read more here.
Keywords: regulatory cells; damage associated; myeloid derived; disease ... See more keywords
BACTERIAL PATHOGEN–ASSOCIATED MOLECULAR PATTERNS UPREGULATE HUMAN GLUCOCORTICOID RECEPTOR EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002004
Abstract: ABSTRACT It is well known that bacterial components (pathogen-associated molecular patterns [PAMPs]) induce a proinflammatory response through pattern recognition receptor signaling. What is not known, however, is how the inflammatory response is downregulated. We hypothesize… read more here.
Keywords: molecular patterns; expression; hgr; associated molecular ... See more keywords
NEUTROPHIL HETEROGENEITY IN SEPSIS: THE ROLE OF DAMAGE-ASSOCIATED MOLECULAR PATTERNS
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002019
Abstract: ABSTRACT Sepsis is a severe inflammatory disease syndrome caused by the dysregulated host response to infection. Neutrophils act as the first line of defense against pathogens by releasing effector molecules such as reactive oxygen species,… read more here.
Keywords: sepsis; heterogeneity; damage associated; damage ... See more keywords