Dissecting Molecular Phenotypes Through FACS-Based Pooled CRISPR Screens.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/7651_2021_457
Abstract: Pooled CRISPR screens are emerging as a powerful tool to dissect regulatory networks, by assessing how a protein responds to genetic perturbations in a highly multiplexed manner. A large number of genes are perturbed in… read more here.
Keywords: molecular phenotypes; crispr screens; facs based; dissecting molecular ... See more keywords
The molecular phenotypes of ureteral telocytes are layer-specific.
Sign Up to like & getrecommendations! Published in 2018 at "Acta histochemica"
DOI: 10.1016/j.acthis.2017.11.003
Abstract: Telocytes (TC) are the delicate interstitial (stromal) cells defined by their long, thin and moniliform processes termed telopodes. Numerous studies determined that different subsets of telocytes populate almost all tissues and attempted to relate these… read more here.
Keywords: tcs; molecular pattern; specific molecular; molecular phenotypes ... See more keywords
Gynaecological neoplasms in common familial syndromes (Lynch and HBOC).
Sign Up to like & getrecommendations! Published in 2018 at "Pathology"
DOI: 10.1016/j.pathol.2017.10.010
Abstract: Recognising hereditary predisposition in a cancer patient has implications both for the patient and the patient's kindred. For the latter, cascade germline testing can reassure those not-at-risk family members while carriers can be enrolled in… read more here.
Keywords: common familial; germline somatic; neoplasms common; gynaecological neoplasms ... See more keywords
Type-2-low severe asthma endotypes for new treatments: the new asthma frontier.
Sign Up to like & getrecommendations! Published in 2023 at "Current opinion in allergy and clinical immunology"
DOI: 10.1097/aci.0000000000000899
Abstract: PURPOSE OF REVIEW Type-2 (T2)-high asthma represents a well defined group of severe eosinophilic asthma for which there are now effective biologic therapies targetting the interleukins (ILs) 4, 5 and 13, and Immunoglobulin E. T2-low… read more here.
Keywords: molecular phenotypes; asthma endotypes; asthma; type low ... See more keywords
The distribution of intratumoral macrophages correlates with molecular phenotypes and impacts prognosis in colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Histopathology"
DOI: 10.1111/his.13674
Abstract: The role of tumour‐associated macrophages (TAMs) in colorectal cancer (CRC) remains elusive. In this study, we aimed to examine the correlation between TAMs, clinicopathological features, tumour‐infiltrating lymphocytes (TILs) and prognosis in CRC by the use… read more here.
Keywords: macrophages correlates; correlates molecular; intratumoral macrophages; distribution intratumoral ... See more keywords
Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time.
Sign Up to like & getrecommendations! Published in 2024 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202308-1490oc
Abstract: RATIONALE Two molecular phenotypes have been identified in acute respiratory distress syndrome (ARDS). In the ROSE trial of cisatracurium in moderate-severe ARDS, we addressed three unanswered questions: 1) Do the same phenotypes emerge in a… read more here.
Keywords: molecular phenotypes; gene expression; ards rose; rose trial ... See more keywords
Single sample scoring of molecular phenotypes
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2435-4
Abstract: BackgroundGene set scoring provides a useful approach for quantifying concordance between sample transcriptomes and selected molecular signatures. Most methods use information from all samples to score an individual sample, leading to unstable scores in small… read more here.
Keywords: sample; data sets; method; single sample ... See more keywords
Precise measurement of molecular phenotypes with barcode-based CRISPRi systems
Sign Up to like & getrecommendations! Published in 2025 at "Genome Biology"
DOI: 10.1186/s13059-025-03610-w
Abstract: Genome-wide CRISPR-Cas9 screens have untangled regulatory networks driving diverse biological processes. Their success relies on interrogating specific molecular phenotypes and distinguishing key regulators from background effects. Here, we realize these goals by optimizing CRISPR interference… read more here.
Keywords: molecular phenotypes; barcode based; ciber seq; phenotypes barcode ... See more keywords
Nomograms for Prediction of Molecular Phenotypes in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s234495
Abstract: Background Colorectal cancer (CRC) patients with different molecular phenotypes, including microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS gene, vary in treatment response and prognosis. However, molecular phenotyping… read more here.
Keywords: kras mutation; braf mutation; molecular phenotypes; colorectal cancer ... See more keywords
Necroptosis Identifies Novel Molecular Phenotypes and Influences Tumor Immune Microenvironment of Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.934494
Abstract: This study aims to investigate the immune and epigenetic mutational landscape of necroptosis in lung adenocarcinoma (LUAD), identify novel molecular phenotypes, and develop a prognostic scoring system based on necroptosis regulatory molecules for a better… read more here.
Keywords: necroptosis; lung adenocarcinoma; molecular phenotypes; immune microenvironment ... See more keywords