Tuning the Hydrophilic - Hydrophobic Balance of Molecular Polymer Bottlebrushes Enhances their Tumor Homing Properties.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202200163
Abstract: Nanoparticle (NP)-based drug delivery systems are promising in anti-cancer therapy, capable of delivering cargo with superior selectivity and achieving enhanced tumor accumulation compared to small-molecule therapeutics. As more efforts are being devoted to NP development,… read more here.
Keywords: tumor; hydrophilic hydrophobic; molecular polymer; hydrophobic balance ... See more keywords
Synthesis of Polypeptoid-Polycaprolactone-Polytetrahydrofuran Heterograft Molecular Polymer Brushes via a Combination of Janus Polymerization and ROMP.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201800905
Abstract: Janus polymerization is a novel and efficient way to synthesize diblock and multiblock copolymers in one step by using Lu(OTf)3 and propylene epoxide as a catalytic system. By modifying the epoxide initiator, which is located… read more here.
Keywords: polymerization; janus polymerization; polymer brushes; heterograft molecular ... See more keywords
Cylindrical Zwitterionic Particles via Interpolyelectrolyte Complexation on Molecular Polymer Brushes.
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DOI: 10.1002/marc.202000401
Abstract: The fabrication of macromolecular architectures with high aspect ratio and well-defined internal and external morphologies remains a challenge. The combination of template chemistry and self-assembly concepts to construct peculiar polymer architectures via a bottom-up approach… read more here.
Keywords: via interpolyelectrolyte; interpolyelectrolyte complexation; complexation; polymer ... See more keywords
Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids
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DOI: 10.1039/c8py00703a
Abstract: Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry where only the aspect-ratio is… read more here.
Keywords: aspect ratio; chemistry; polymer brushes; polymer ... See more keywords
Molecular polymer bottlebrushes in nanomedicine: therapeutic and diagnostic applications.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01601j
Abstract: Molecular polymer bottlebrushes are densely grafted, individual macromolecules with nanoscale proportions. The last decade has seen an increased focus on this material class, especially in nanomedicine and for biomedical applications. This Feature Article provides an… read more here.
Keywords: therapeutic diagnostic; bottlebrushes nanomedicine; nanomedicine therapeutic; polymer bottlebrushes ... See more keywords