Chronic myeloid leukemia without major molecular response after 2 years of treatment with tyrosine kinase inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26836
Abstract: Achieving major molecular response (MMR) with BCR::ABL1 tyrosine kinase inhibitors (TKIs) is associated with lower chances of progression to advanced phase disease and higher chances of treatment‐free remission (TFR) in patients with chronic myeloid leukemia… read more here.
Keywords: year; cml; major molecular; treatment ... See more keywords
Deep molecular response in patients with chronic phase chronic myeloid leukemia treated with the plasminogen activator inhibitor‐1 inhibitor TM5614 combined with a tyrosine kinase inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5292
Abstract: We recently showed that pharmacological inhibition of plasminogen activator inhibitor‐1 (PAI‐1) activity, based on TM5614, increases cell motility and induces the detachment of hematopoietic stem cells from their niches. In this TM5614 phase II clinical… read more here.
Keywords: deep molecular; activator inhibitor; plasminogen activator; inhibitor ... See more keywords
Prognostic factors for progression in patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia in complete molecular response within 3 months of therapy with tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer"
DOI: 10.1002/cncr.33529
Abstract: The achievement of a 3‐month complete molecular response (CMR) is a major prognostic factor for survival in patients with Philadelphia chromosome (Ph)‐positive acute lymphoblastic leukemia (ALL). However, 25% of patients relapse during therapy with tyrosine… read more here.
Keywords: molecular response; positive acute; patients philadelphia; complete molecular ... See more keywords
Impact of obesity on the molecular response to a single bout of exercise in a preliminary human cohort
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23419
Abstract: The health benefits of exercise are well documented, but several exercise‐response parameters are attenuated in individuals with obesity. The goal of this pilot study was to identify molecular mechanisms that may influence exercise response with… read more here.
Keywords: response; impact obesity; molecular response; exercise ... See more keywords
Physiological and Molecular Response of Arabidopsis thaliana to CuO Nanoparticle (nCuO) Exposure
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Environmental Contamination and Toxicology"
DOI: 10.1007/s00128-017-2205-4
Abstract: The widespread application of copper oxide nanoparticles (nCuO) results in ecological risk when nanoparticles enter the environment. This study clarifies the mechanism of nCuO toxicity in Arabidopsis thaliana seedlings via comparison with copper (Cu) ion… read more here.
Keywords: arabidopsis thaliana; molecular response; physiological molecular; exposure ... See more keywords
Relationship between achievement of major molecular response or deep molecular response and nilotinib plasma concentration in patients with chronic myeloid leukemia receiving first-line nilotinib therapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-022-04419-1
Abstract: We evaluated the plasma exposure and response relationships of nilotinib for patients with newly diagnosed chronic myeloid leukemia (CML) in real-world practice. For the 26 patients enrolled in this study, at 3, 6, 12, and… read more here.
Keywords: response; concentration; molecular response; nilotinib ctrough ... See more keywords
An analysis of the kinetics of molecular response during the first trimester of treatment with nilotinib in newly diagnosed chronic myeloid leukemia patients in chronic phase
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-017-2445-z
Abstract: PurposeThis study was aimed to analyze the association of very early molecular response to nilotinib with the achievement of deep molecular response (MR4) at 18 months. We hypothesized that the BCR-ABL1 levels during the first 3 months… read more here.
Keywords: response; molecular response; myeloid leukemia; patients chronic ... See more keywords
Results of the European survey on the assessment of deep molecular response in chronic phase CML patients during tyrosine kinase inhibitor therapy (EUREKA registry)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-02910-6
Abstract: PurposeThe advent of tyrosine kinase inhibitor (TKI) therapies has revolutionized the treatment of chronic myeloid leukemia (CML). The European LeukemiaNet (ELN) recommends quantification of BCR–ABL1 transcripts by real-time quantitative PCR every 3 months during TKI treatment.… read more here.
Keywords: response; molecular response; deep molecular; kinase inhibitor ... See more keywords
Molecular response uncovers neurotoxicity of Pardosa pseudoannulata exposed to cadmium pressure.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.117000
Abstract: Cadmium (Cd) is a widely distributed heavy metal in south of China. Growing evidence indicates that systemic exposure to Cd, particularly the long-term exposure, may cause neurotoxic effects. Nevertheless, mechanisms underlying Cd neurotoxicity remain not… read more here.
Keywords: pardosa pseudoannulata; term; molecular response; exposure ... See more keywords
Molecular response of a sub-antarctic population of the blue mussel (Mytilus edulis platensis) to a moderate thermal stress.
Sign Up to like & getrecommendations! Published in 2021 at "Marine environmental research"
DOI: 10.1016/j.marenvres.2021.105393
Abstract: The Kerguelen Islands (49°26'S, 69°50'E) represent a unique environment due to their geographical isolation, which protects them from anthropogenic pollution. The ability of the endemic mussel, part of the Mytilus complex, to cope with moderate… read more here.
Keywords: response; molecular response; mussel; stress ... See more keywords
Dynamics of molecular response in AML patients with NPM1 and FLT3 mutations undergoing allogeneic stem cell transplant
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DOI: 10.1038/bmt.2017.82
Abstract: Dynamics of molecular response in AML patients with NPM1 and FLT3 mutations undergoing allogeneic stem cell transplant read more here.
Keywords: aml patients; dynamics molecular; molecular response; response aml ... See more keywords