Molecular signatures in hepatocellular carcinoma: A step toward rationally designed cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31257
Abstract: Molecular characterization of hepatocellular carcinoma (HCC) has greatly improved our understanding of disease pathogenesis. Mutational analysis, RNA and microRNA expression profiling, and epigenetic characterization have revealed common aberrations in oncogenes and tumor suppressors that correlate… read more here.
Keywords: hepatocellular carcinoma; molecular signatures; biology; cancer ... See more keywords
Systems Biology Methods for Alzheimer's Disease Research Toward Molecular Signatures, Subtypes, and Stages and Precision Medicine: Application in Cohort Studies and Trials.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7704-8_3
Abstract: Alzheimer's disease (AD) is a complex multifactorial disease, involving a combination of genomic, interactome, and environmental factors, with essential participation of (a) intrinsic genomic susceptibility and (b) a constant dynamic interplay between impaired pathways and… read more here.
Keywords: medicine; biology methods; disease; biology ... See more keywords
Transcriptomics-based screening of molecular signatures associated with patients overall survival and their key regulators in subtypes of breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.09.004
Abstract: Molecular subtypes of breast cancer are associated with differences in prognosis and strategies of molecular targeted therapies. Gene regulatory mechanisms as one of the reasons might modulate these differences. In the present study, we proposed a comprehensive… read more here.
Keywords: molecular signatures; subtypes breast; breast cancer; cancer ... See more keywords
Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69691-8
Abstract: Acute myeloid leukemia (AML) is a very heterogeneous and highly malignant blood cancer. Mutations of the DNA methyltransferase DNMT3A are among the most frequent recurrent genetic lesions in AML. The majority of DNMT3A-mutant AML patients… read more here.
Keywords: survival differences; aml patients; myeloid leukemia; dnmt3a mutant ... See more keywords
Molecular signatures of anthroponotic cutaneous leishmaniasis in the lesions of patients infected with Leishmania tropica
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72671-7
Abstract: Anthroponotic cutaneous leishmaniasis (CL) caused by Leishmania tropica (L. tropica) represents a public health challenge in several resource poor settings. We herein employed a systems analysis approach to study molecular signatures of CL caused by… read more here.
Keywords: tropica; lesions patients; molecular signatures; cutaneous leishmaniasis ... See more keywords
Multimodal high-resolution nano-DESI MSI and immunofluorescence imaging reveal molecular signatures of skeletal muscle fiber types
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc06020e
Abstract: The skeletal muscle is a highly heterogeneous tissue comprised of different fiber types with varying contractile and metabolic properties. The complexity in the analysis of skeletal muscle fibers associated with their small size (30–50 μm)… read more here.
Keywords: fiber types; fiber; muscle; high resolution ... See more keywords
Molecular Signatures of Lithium Treatment: Current Knowledge.
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacopsychiatry"
DOI: 10.1055/a-0650-4820
Abstract: Lithium (Li) is the key mood stabilizer in the prevention of mood recurrences and suicide in bipolar disorders. However, only one-third of patients become asymptomatic with Li treatment, and to date, no clinical markers can… read more here.
Keywords: signatures lithium; treatment; current knowledge; lithium treatment ... See more keywords
Universal correction of enzymatic sequence bias reveals molecular signatures of protein/DNA interactions
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1053
Abstract: Abstract Coupling molecular biology to high-throughput sequencing has revolutionized the study of biology. Molecular genomics techniques are continually refined to provide higher resolution mapping of nucleic acid interactions and structure. Sequence preferences of enzymes can… read more here.
Keywords: biology; sequence bias; molecular signatures; sequence ... See more keywords
MBCL-12. MOLECULAR SIGNATURES AND TUMOR INFILTRATING IMMUNOLOGICAL CELLS ASSOCIATED WITH ASIAN MEDULLOBLASTOMA PATIENT SURVIVAL
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.488
Abstract: Abstract BACKGROUND Medulloblastoma is an aggressive pediatric brain tumor with surgery and post-resection radiotherapy plus chemotherapy as the major type of treatment currently. METHODS A cohort of 52 medulloblastoma patients were treated in Taipei Medical… read more here.
Keywords: medulloblastoma; mbcl molecular; tumor infiltrating; molecular signatures ... See more keywords
Environmental and sex-specific molecular signatures of glioma causation.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab103
Abstract: BACKGROUND The relative importance of genetic and environmental risk factors in gliomagenesis remains uncertain. METHODS Using whole-exome sequencing data from 1105 adult gliomas, we evaluate the relative contribution to cancer cell lineage proliferation and survival… read more here.
Keywords: molecular signatures; sex specific; sex; specific molecular ... See more keywords
Molecular signatures of the glass transition in polymers.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.106.014506
Abstract: The glass transition temperature (T_{g}) is one of the most fundamental properties of polymers. T_{g} is predicted by some theories as a sudden change in a "macroscopic" quantity (e.g., compressibility). However, for systems with "soft"… read more here.
Keywords: transition polymers; transition; glass transition; temperature ... See more keywords