Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neuroradiology"
DOI: 10.1007/s00062-021-01120-3
Abstract: Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1… read more here.
Keywords: molecular subgroups; diffuse midline; k27m; midline glioma ... See more keywords
Plasma cells expression from smouldering myeloma to myeloma reveals the importance of the PRC2 complex, cell cycle progression, and the divergent evolutionary pathways within the different molecular subgroups
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01379-y
Abstract: Sequencing studies have shed some light on the pathogenesis of progression from smouldering multiple myeloma (SMM) and symptomatic multiple myeloma (MM). Given the scarcity of smouldering samples, little data are available to determine which translational… read more here.
Keywords: molecular subgroups; importance prc2; prc2 complex; myeloma ... See more keywords
IMG-19. RADIOMICS AND SUPERVISED DEEP LEARNING TO PREDICT MOLECULAR SUBGROUPS IN MEDULLOBLASTOMA BASED ON WHOLE TUMOR VOLUME LABELING: A SINGLE CENTER MULTIPARAMETRIC MR ANALYSIS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.354
Abstract: Abstract PURPOSE Medulloblastoma (MB) is a complex pathology. Four molecular subgroups have been unveiled (Wingless-WNT, Sonic Hedgehog-SHH, Group 3-G3 and Group 4-G4), characterized by significant differences in patient clinical outcome. We investigated the utility of… read more here.
Keywords: molecular subgroups; volume; analysis; relevant features ... See more keywords
P12.06 Clinicopathological evaluation of PD-L1 expression and cytotoxic T-lymphocyte infiltrates across intracranial molecular subgroups of ependymomas
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.217
Abstract: Immune check-point blockade targeting programmed cell death ligand-1 (PD-L1)/programmed death-1 (PD-1) axis has created paradigm shift in the treatment of advanced cancer. The prognosis of the ‘ST-RELA’ and ‘PF-A’ molecular subgroups of ependymomas (EPN) remains… read more here.
Keywords: rela; molecular subgroups; subgroups ependymomas; epns ... See more keywords
Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2018-09-872549
Abstract: Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the 2 most frequent categories, accounting for… read more here.
Keywords: ptcl gata3; molecular subgroups; ptcl; cell ... See more keywords
Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Egyptian National Cancer Institute"
DOI: 10.1186/s43046-021-00060-w
Abstract: Medulloblastoma (MB) is a heterogeneous disease, displaying distinct genetic profiles with specific molecular subgroups. This study aimed to validate MB molecular subgrouping using surrogate immunohistochemistry and associate molecular subgroups, histopathological types, and available clinicopathological parameters… read more here.
Keywords: molecular subgroups; risk stratification; shh; clinicopathological parameters ... See more keywords
Clinical factors as prognostic variables among molecular subgroups of endometrial cancer
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DOI: 10.1371/journal.pone.0242733
Abstract: Background Clinical factors may influence endometrial cancer survival outcomes. We examined the prognostic significance of age, body mass index (BMI), and type 2 diabetes among molecular subgroups of endometrial cancer. Methods This was a single… read more here.
Keywords: molecular subgroups; related mortality; cancer related; endometrial cancer ... See more keywords
MR Imaging–Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a5899
Abstract: BACKGROUND AND PURPOSE: Distinct molecular subgroups of pediatric medulloblastoma confer important differences in prognosis and therapy. Currently, tissue sampling is the only method to obtain information for classification. Our goal was to develop and validate… read more here.
Keywords: distinct molecular; area; imaging based; based radiomic ... See more keywords
Integrated genomic analysis defines molecular subgroups in dilated cardiomyopathy and identifies novel biomarkers based on machine learning methods
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1050696
Abstract: Aim: As the most common cardiomyopathy, dilated cardiomyopathy (DCM) often leads to progressive heart failure and sudden cardiac death. This study was designed to investigate the molecular subgroups of DCM. Methods: Three datasets of DCM… read more here.
Keywords: molecular subgroups; analysis; gene expression; gene ... See more keywords
Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm13050723
Abstract: The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the… read more here.
Keywords: endometrial carcinoma; molecular subgroups; impact; pathologic ... See more keywords
Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma.
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DOI: 10.3892/ol.2018.9539
Abstract: Lung microinvasive adenocarcinoma (MIA) is a newly-defined subtype of early stage non-small cell lung cancer (NSCLC). However, its epidermal growth factor receptor (EGFR) mutation status and clinical significance remain unclear. The present study aimed to… read more here.
Keywords: molecular subgroups; present study; mia; factor ... See more keywords