Molecular‐Switch‐Embedded Solution‐Processed Semiconductors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202203401
Abstract: Recent improvements in the performance of solution‐processed semiconductor materials and optoelectronic devices have shifted research interest to the diversification/advancement of their functionality. Embedding a molecular switch capable of transition between two or more metastable isomers… read more here.
Keywords: solution processed; switch; molecular switch; molecular switches ... See more keywords
Conformational states of TNFR1 as a molecular switch for receptor function
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3829
Abstract: Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that plays a key role in the regulation of the inflammatory pathway. While inhibition of TNFR1 has been the focus of many studies for the… read more here.
Keywords: receptor; receptor function; conformational states; molecular switch ... See more keywords
Miro: A molecular switch at the center of mitochondrial regulation
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3839
Abstract: The orchestration of mitochondria within the cell represents a critical aspect of cell biology. At the center of this process is the outer mitochondrial membrane protein, Miro. Miro coordinates diverse cellular processes by regulating connections… read more here.
Keywords: miro molecular; switch center; miro; center ... See more keywords
Flipping the Molecular Switch: Influence of Perlecan and Its Modifiers in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-40146-7_6
Abstract: The tumor microenvironment (TME) is rich in matrix components, growth factors, cytokines, and enzymatic modifiers that respond to changing conditions, to alter the fundamental properties of the tumor bed. Perlecan/HSPG2, a large, multi-domain heparan sulfate… read more here.
Keywords: perlecan modifiers; stroma; influence; tumor microenvironment ... See more keywords
A Common Molecular Switch for H2S to Regulate Multiple Protein Targets.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-0991-6_1
Abstract: Hydrogen sulfide, a small molecule, produced by endogenous enzymes, such as CTH, CBS, and MPST using L-cysteine as substrates, has been reported to have numerous protective effects. However, the key problem that the target of… read more here.
Keywords: common molecular; protein targets; switch h2s; molecular switch ... See more keywords
Twisted chromophore assist to tetrathiafulvalene-spiropyran hybrid driving four-state molecular switch
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2020.112915
Abstract: Abstract A series of novel molecular hybrids, in which tetrathiafulvalene (TTF) unit and spiropyran (SP) core are covalently linked to various typical π-conjugated bridges, has been designed based on auxiliary donors and acceptors model and… read more here.
Keywords: second order; chromophore assist; twisted chromophore; assist tetrathiafulvalene ... See more keywords
The Notch-3 receptor: A molecular switch to tumorigenesis?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2017.08.011
Abstract: The Notch pathway is a highly conserved pathway increasingly implicated with the progression of human cancers. Of the four existing receptors associated with the pathway, the deregulation in the expression of the Notch-3 receptor is… read more here.
Keywords: receptor molecular; notch receptor; receptor; switch tumorigenesis ... See more keywords
A multi-responsive molecular switch based on a diarylethene derivative containing dinitrobenzenesulfonic amide groups
Sign Up to like & getrecommendations! Published in 2017 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2016.08.072
Abstract: Abstract Diarylethene derivatives-based multi-responsive molecular switches are indispensable for application to sensors for biological and materials sciences. The constructing of molecular switches that can respond to sulfur compounds remains a challenge. In this work, we… read more here.
Keywords: multi responsive; switch; switch based; responsive molecular ... See more keywords
Molecular switch manipulating Prelog priority of an alcohol dehydrogenase toward bulky-bulky ketones
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2019.110741
Abstract: Abstract Structure-guided rational design revealed the molecular switch manipulating the Prelog and anti-Prelog priorities of an NADPH-dependent alcohol dehydrogenase toward prochiral ketones with bulky and similar substituents. Synergistic effects of unconserved residues at 214 and… read more here.
Keywords: prelog; manipulating prelog; switch manipulating; alcohol dehydrogenase ... See more keywords
Molecular Switch Engineering for Precise Genome Editing.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00088
Abstract: Genome editing technology commenced in 1996 with the discovery of the first zinc-finger nuclease. Application of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) associated protein 9 (Cas9) technology to genome editing of mammalian cells allowed… read more here.
Keywords: genome editing; genome; molecular switch; switch engineering ... See more keywords
Surface Plasmon Polariton-Controlled Molecular Switch
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.8b05190
Abstract: Molecular electronic devices are studied extensively to explore their potential use in electronics and also to gain an understanding of the mechanisms of electron transport at the molecular scale. Recent experiments show that molecules can… read more here.
Keywords: molecular switch; polariton controlled; surface plasmon; plasmon polariton ... See more keywords