Enrollment Barriers for Molecular Targeted Trials.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2023.0248
Abstract: This quality improvement study examines the difficulties of patient accrual among patients with cancer and SETD2 variants. read more here.
Keywords: barriers molecular; targeted trials; enrollment barriers; molecular targeted ... See more keywords
A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-020-01944-5
Abstract: Acute myeloid leukemia (AML) is an extremely heterogeneous disease defined by the clonal growth of myeloblasts/promyelocytes not only in the bone marrow but also in peripheral blood and/or tissues. Gene mutations and chromosomal abnormalities are… read more here.
Keywords: medicine; myeloid leukemia; molecular targeted; genetic alterations ... See more keywords
Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases
Sign Up to like & getrecommendations! Published in 2019 at "Intensive Care Medicine"
DOI: 10.1007/s00134-019-05650-w
Abstract: BackgroundMolecular targeted therapy increased overall and disease-free survival in a wide range of malignancies. Although generally well tolerated compared to chemotherapy, molecular targeted therapy may be associated with adverse events requiring ICU admission. Informing clinicians… read more here.
Keywords: therapy related; targeted therapy; molecular targeted; life threatening ... See more keywords
The Treatment Landscape and New Opportunities of Molecular Targeted Therapies in Gastroenteropancreatic Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2017 at "Targeted Oncology"
DOI: 10.1007/s11523-017-0532-3
Abstract: Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplasms that originate from neuroendocrine stem cells and express both neural and endocrine markers. They are found in almost every organ, and while NENs are mostly associated… read more here.
Keywords: treatment landscape; landscape new; treatment; molecular targeted ... See more keywords
Imaging of hepatic toxicity of systemic therapy in a tertiary cancer centre: chemotherapy, haematopoietic stem cell transplantation, molecular targeted therapies, and immune checkpoint inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical radiology"
DOI: 10.1016/j.crad.2017.04.003
Abstract: The purpose of this review is to familiarise radiologists with the spectrum of hepatic toxicity seen in the oncology setting, in view of the different systemic therapies used in cancer patients. Drug-induced liver injury can… read more here.
Keywords: chemotherapy; immune checkpoint; checkpoint inhibitors; molecular targeted ... See more keywords
Chemokine receptor CXCR4: An important player affecting the molecular-targeted drugs commonly used in hematological malignancies
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2020.1839885
Abstract: ABSTRACT Introduction A variety of molecular-targeted drugs have been widely used in hematological malignancies and have shown great advances. Nevertheless, as the use of drugs in clinical practice increases, the problem of relapse or of… read more here.
Keywords: molecular targeted; hematological malignancies; targeted drugs; chemokine receptor ... See more keywords
Incidence of opportunistic infections in patients with rheumatoid arthritis treated with different molecular-targeted drugs: A population-based retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Modern rheumatology"
DOI: 10.1093/mr/roac133
Abstract: OBJECTIVE We compared the incidences of four opportunistic infections (OI) in patients with rheumatoid arthritis (RA) treated with molecular-targeted drugs from big claims data. MATERIALS AND METHODS We identified 205 906 patients with RA who… read more here.
Keywords: targeted drugs; incidence; patients rheumatoid; molecular targeted ... See more keywords
Evaluation of the efficiency and safety of combined chemotherapy and molecular-targeted therapy in the treatment of advanced gastric cancer
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000027557
Abstract: Abstract Background: Gastric cancer is considered to be the sixth prevalent cancer and the third widespread trigger of cancer-associated deaths globally. One of the major method of treating this harmful condition is completely resecting the… read more here.
Keywords: molecular targeted; cancer; gastric cancer; advanced gastric ... See more keywords
Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer‐associated fibroblast
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15502
Abstract: Cancer‐associated fibroblasts (CAFs) are a major component of the tumor microenvironment that mediate resistance of cancer cells to anticancer drugs. Tranilast is an antiallergic drug that suppresses the release of cytokines from various inflammatory cells.… read more here.
Keywords: therapy; molecular targeted; nsclc cells; drug ... See more keywords
Molecular‐targeted therapy in advanced renal cell carcinoma based on pharmacokinetics, pharmacodynamics and pharmacogenetics: A proposed strategy
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Urology"
DOI: 10.1111/iju.13805
Abstract: In advanced renal cell carcinoma, a transition of drug therapies from cytokines to molecular‐targeted drugs and immune‐oncology drugs provides more clinical benefits to patients, while adequate management is required for various and sometimes serious adverse… read more here.
Keywords: renal cell; cell carcinoma; molecular targeted; pharmacodynamics pharmacogenetics ... See more keywords
Extremely High Objective Response Rate of Lenvatinib: Its Clinical Relevance and Changing the Treatment Paradigm in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Liver Cancer"
DOI: 10.1159/000492533
Abstract: The results of a clinical trial of lenvatinib were published in the Lancet earlier this year [1]. According to the results, the response rate was higher for lenvatinib than for any other known molecular targeted… read more here.
Keywords: response; treatment; molecular targeted; objective response ... See more keywords