Regulation of Multifunctional Calcium/Calmodulin Stimulated Protein Kinases by Molecular Targeting.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_26
Abstract: Multifunctional calcium/calmodulin-stimulated protein kinases control a broad range of cellular functions in a multitude of cell types. This family of kinases contain several structural similarities and all are regulated by phosphorylation, which either activates, inhibits… read more here.
Keywords: multifunctional calcium; protein kinases; calmodulin stimulated; molecular targeting ... See more keywords
Nanomedicine-driven molecular targeting, drug delivery, and therapeutic approaches to cancer chemoresistance.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.12.016
Abstract: Cancer cell resistance to chemotherapeutics (chemoresistance) poses a significant clinical challenge that oncology research seeks to understand and overcome. Multiple anticancer drugs and targeting agents can be incorporated in nanomedicines, in addition to different treatment… read more here.
Keywords: chemoresistance; driven molecular; molecular targeting; drug ... See more keywords
Molecular Targeting of Immunosuppressants Using a Bi-functional Elastin-Like Polypeptide.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00462
Abstract: Elastin-Like Polypeptides (ELP) are environmentally-responsive protein polymers which are easy to engineer and biocompatible, making them ideal candidates as drug carriers. Our team has recently utilized ELPs fused to FKBP12 to carry Rapamycin (Rapa), a… read more here.
Keywords: rapa; male nod; molecular targeting; elastin like ... See more keywords
Effects of nivolumab alone or combination with molecular targeting agents for recurrent and refractory endometrial cancers with biomarker analyses.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e17124
Abstract: e17124 Background: The immunotherapy drug, nivolumab, is now approved for several metastatic cancers, and has resulted in responses previously not seen with these cancers. Molecular targeting agents, such as mammalian target of rapamycin (mTOR) inhibitor,… read more here.
Keywords: histology; targeting agents; molecular targeting; alone combination ... See more keywords
Molecular Targeting of ERKs/RSK2 Signaling in Cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Current pharmaceutical design"
DOI: 10.2174/1381612823666170714142338
Abstract: Accumulating studies have provided concrete evidence that p90 ribosomal S6 kinase 2 (RSK2) is a key signaling molecule involved in cell proliferation, transformation, and cancer development. RSK2 is known to be an etiological gene of… read more here.
Keywords: molecular targeting; rsk2; targeting erks; rsk2 signaling ... See more keywords
Molecular Targeting and Novel Therapeutic approaches against Fungal Infections
Sign Up to like & getrecommendations! Published in 2023 at "Current Molecular Medicine"
DOI: 10.2174/1566524023666230302123310
Abstract: Fungal infections have become a worldwide problem due to their involvement in numerous diseases. The risk factors for fungal infections are multiple surgeries, transplant therapies, frequent administration of antibiotics, cancer treatments, and prosthetic devices. The… read more here.
Keywords: targeting novel; novel therapeutic; antifungal drugs; resistance ... See more keywords
Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01260
Abstract: Chemoradiation, either alone or in combination with surgery or induction chemotherapy, is the current standard of care for most locally advanced solid tumors. Though chemoradiation is usually performed at the maximum tolerated doses of both… read more here.
Keywords: tumor radiosensitization; molecular targeting; efficacy; chemoradiation ... See more keywords