Identification and characterization of key genes in insulin signaling pathway as molecular targets for controlling the fall webworm, Hyphantria cunea.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7268
Abstract: BACKGROUND The insulin signaling pathway is closely related to metabolism, growth, reproductive capacity, and lifespan of insects. However, the physiological function of the insulin signaling pathway is little known in Hyphantria cunea. RESULTS Five insulin… read more here.
Keywords: signaling pathway; cunea; molecular targets; hyphantria cunea ... See more keywords
Octopus: a platform for the virtual high-throughput screening of a pool of compounds against a set of molecular targets
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-016-3184-9
Abstract: AbstractOctopus is an automated workflow management tool that is scalable for virtual high-throughput screening (vHTS). It integrates MOPAC2016, MGLTools, PyMOL, and AutoDock Vina. In contrast to other platforms, Octopus can perform docking simulations of an… read more here.
Keywords: virtual high; high throughput; set molecular; compounds set ... See more keywords
Molecular Targets of Natriuretic Action of Prolactin in the Rat Model of Cholestasis of Pregnancy
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04678-8
Abstract: We analyzed the expression of molecular targets of natriuretic action of prolactin in different layers of the kidney in the rat model of cholestasis of pregnancy. Sodium bicarbonate cotransporter NBCe1 was most sensitive to the… read more here.
Keywords: prolactin; targets natriuretic; cholestasis pregnancy; cholestasis ... See more keywords
Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host
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DOI: 10.1007/s11888-017-0362-9
Abstract: Purpose of ReviewThe relationship between colonic bacteria and the host is symbiotic, but how communication between the two partners occurs is just beginning to be understood at the molecular level. Here, we highlight specific products… read more here.
Keywords: targets host; colon; bacterial metabolites; gut microbiome ... See more keywords
Current anti-diabetic agents and their molecular targets: A review.
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DOI: 10.1016/j.ejmech.2018.04.061
Abstract: Diabetes mellitus is a medical condition characterized by the body's loss of control over blood sugar. The frequency of diagnosed cases and consequential increases in medical costs makes it a rapidly growing chronic disease that… read more here.
Keywords: current anti; diabetic agents; diabetes mellitus; anti diabetic ... See more keywords
Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2019.02.033
Abstract: Diabetes mellitus (DM), a chronic metabolic disease, severely affects patients' life and intensively increases risks of developing other diseases. It is estimated that 0.4 billion individuals worldwide are subjected to diabetes, especially type 2 diabetes… read more here.
Keywords: identification molecular; type diabetes; diabetes mellitus; anti diabetic ... See more keywords
Molecular Targets Beyond the Big 3.
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DOI: 10.1016/j.thorsurg.2020.01.004
Abstract: Lung cancer is a heterogeneous genomic disease. Smoking remains the primary cause. Genetic susceptibility and environmental exposures are responsible for 10% to 15% of cases. Targeted therapies improve survival in patients with tumors with oncogenic… read more here.
Keywords: targets beyond; beyond big; molecular targets; lung cancer ... See more keywords
Molecular targets for the development of new acaricides against Rhipicephalus microplus: a review
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DOI: 10.1017/s0031182022000506
Abstract: Abstract Abstract The cattle tick Rhipicephalus microplus is an ectoparasite with high economic importance to bovine culture, mainly in tropical and subtropical regions. The resistance of the tick from the commercial acaricides has hindered its… read more here.
Keywords: review; development new; new acaricides; molecular targets ... See more keywords
PUFA-Derived N-Acylethanolamide Probes Identify Peroxiredoxins and Small GTPases as Molecular Targets in LPS-Stimulated RAW264.7 Macrophages
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DOI: 10.1021/acschembio.1c00355
Abstract: We studied the mechanistic and biological origins of anti-inflammatory poly-unsaturated fatty acid-derived N-acylethanolamines using synthetic bifunctional chemical probes of docosahexaenoyl ethanolamide (DHEA) and arachidonoyl ethanolamide (AEA) in RAW264.7 macrophages stimulated with 1.0 μg mL–1 lipopolysaccharide.… read more here.
Keywords: molecular targets; dhea aea; microscopy; raw264 macrophages ... See more keywords
Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets
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DOI: 10.1038/s41598-018-22228-6
Abstract: Tuberculosis remains a serious threat to human health world-wide, and improved efficiency of medical treatment requires a better understanding of the pathogenesis and the discovery of new drugs. In the present study, we performed a… read more here.
Keywords: infective activity; new molecular; drug discovery; antimycobacterial drug ... See more keywords
Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25500-x
Abstract: Increasing evidence has shown that Chinese herbal medicine (CHM) has promising therapeutic effects in colorectal cancer (CRC); however, the active ingredients and potential targets remain unclear. In this study, we aimed to investigate the relative… read more here.
Keywords: colorectal cancer; chinese herbs; targets chinese; pharmacology ... See more keywords