Bioelectrodes for evaluating molecular therapeutic and toxicity properties
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Electrochemistry"
DOI: 10.1016/j.coelec.2019.09.004
Abstract: Abstract Recent progress on material designs merged with nanotechnology and biotechnology strategies has advanced studies of complex biological samples on electrodes for cytochrome P450 (CYP)–driven biocatalytic reactions (e.g. liver membrane fractions, cells, and various organ-specific CYP… read more here.
Keywords: bioelectrodes evaluating; therapeutic toxicity; molecular therapeutic; toxicity properties ... See more keywords
Emerging molecular therapeutic targets for cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.03.026
Abstract: Cholangiocarcinomas (CCAs) are diverse epithelial tumors arising from the liver or large bile ducts with features of cholangiocyte differentiation. CCAs are classified anatomically into intrahepatic (iCCA), perihilar (pCCA), and distal CCA (dCCA). Each subtype has… read more here.
Keywords: molecular therapeutic; therapeutic targets; cca; emerging molecular ... See more keywords
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109440
Abstract: There are a pretty number of research demonstrating that ADAMTS4 and ADAMTS5 playing primary roles in the degradation of cartilage during inflammatory joint diseases like osteoarthritis (OA). Because Kashin-Beck Disease (KBD) has been found to… read more here.
Keywords: adamts4 adamts5; adamts5 may; molecular therapeutic; therapeutic targets ... See more keywords
A Multifunctional Molecular Therapeutic Agent for Targeted and Controlled Dual Chemo- and Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00893
Abstract: A novel molecular therapeutic agent was designed and synthesized which contains three functional components, namely a zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate (DNBS) group as a glutathione (GSH)-activated photosensitizer, a chemo-prodrug based on combretastatin A-4… read more here.
Keywords: therapeutic agent; multifunctional molecular; chemo; molecular therapeutic ... See more keywords
Role of Gut Microbiome in Atherosclerosis: Molecular and Therapeutic Aspects.
Sign Up to like & getrecommendations! Published in 2023 at "Current cardiology reviews"
DOI: 10.2174/1573403x19666230202164524
Abstract: Atherosclerosis is one of the most relevant and prevalent cardiovascular diseases of our time. It is one of the pathological entities that increases the morbidity and mortality index in the adult population. Pathophysiological connections have… read more here.
Keywords: molecular therapeutic; atherosclerosis; role gut; gut microbiome ... See more keywords
Transcriptome Profiling and Molecular Therapeutic Advances in Cystic Fibrosis: Recent Insights
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10030180
Abstract: In cystic fibrosis (CF), mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene disrupt the capacity of the encoded protein to function as a channel to transport chloride ions and water across cell membranes.… read more here.
Keywords: cystic fibrosis; molecular therapeutic; transcriptome profiling; gene ... See more keywords
Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20081948
Abstract: Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in developed countries but its diffusion is currently also emerging in Asian countries, in South America and in other developing countries. It is… read more here.
Keywords: fatty liver; molecular therapeutic; disease; nonalcoholic fatty ... See more keywords
Identification of Gαi3 as a novel molecular therapeutic target of cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.77126
Abstract: Here we studied expression and potential functions of Gαi3 in cervical cancer. The bioinformatics analysis together with the results from local patients' tissues revealed that Gαi3 expression was remarkably elevated in human cervical cancer tissues… read more here.
Keywords: cervical cancer; cancer; molecular therapeutic; novel molecular ... See more keywords