Inferring biologically relevant molecular tissue substructures by agglomerative clustering of digitized spatial transcriptomes with multilayer.
Sign Up to like & getrecommendations! Published in 2021 at "Cell systems"
DOI: 10.1016/j.cels.2021.04.008
Abstract: Spatially resolved transcriptomics (SrT) can investigate organ or tissue architecture from the angle of gene programs that define their molecular complexity. However, computational methods to analyze SrT data underexploit their spatial signature. Inspired by contextual… read more here.
Keywords: agglomerative clustering; tissue; relevant molecular; molecular tissue ... See more keywords
Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels
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DOI: 10.3389/fphys.2016.00659
Abstract: Inherited cardiomyopathies are a common form of heart disease that are caused by mutations in sarcomeric proteins with beta cardiac myosin (MYH7) being one of the most frequently affected genes. Since the discovery of the… read more here.
Keywords: myosin; molecular tissue; force; beta cardiac ... See more keywords
Molecular Tissue Responses to Mechanical Loading
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042074
Abstract: The intention of this special edition is to highlight the benefits of a holistic approach to computational and experimental approaches in the context of aiding the diagnosis and remediation of disease and injury, especially in… read more here.
Keywords: molecular tissue; responses mechanical; mechanical loading; tissue responses ... See more keywords