Design molecular topology for wet-dry adhesion.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b07522
Abstract: Recent innovations highlight the integration of diverse materials with synthetic and biological hydrogels. Examples include brain-machine interfaces, tissue regeneration, and soft ionic devices. Existing methods of strong adhesion mostly focus on the chemistry of bonds… read more here.
Keywords: chemistry; adhesion; molecular topology; topology ... See more keywords
Synthesis of conjugated segment-based cyclic polymers for direct imaging of the cyclic molecular topology.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07223d
Abstract: Conjugated polyacetylene-based monocyclic and bicyclic polymers were synthesized by blocking-cyclization metathesis polymerization using short ladderphanes as the initial motif and multi-cyclizing unit, and fully characterized to elucidate the cyclic characteristics and good photoelectric properties. Importantly,… read more here.
Keywords: topology; cyclic polymers; segment based; synthesis conjugated ... See more keywords
What place does molecular topology have in today’s drug discovery?
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2020.1770223
Abstract: ABSTRACT Introduction Most methods in molecular and drug design are currently based on physicochemical descriptors. However, molecular topology, which relies on topological descriptors, has also shown value for molecular design even if it does not… read more here.
Keywords: molecular topology; topology; discovery place; drug discovery ... See more keywords
How Molecular Topology Can Help in Amyotrophic Lateral Sclerosis (ALS) Drug Development: A Revolutionary Paradigm for a Merciless Disease
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15010094
Abstract: Even if amyotrophic lateral sclerosis is still considered an orphan disease to date, its prevalence among the population is growing fast. Despite the efforts made by researchers and pharmaceutical companies, the cryptic information related to… read more here.
Keywords: topology; disease; lateral sclerosis; molecular topology ... See more keywords