High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1
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DOI: 10.1002/1878-0261.12434
Abstract: Polybromo‐1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl‐lysine residues. While BD2 has been found to bind acetylated histone H3 lysine… read more here.
Keywords: tumor suppressor; molecular tumor; binding h3k14ac; tumor ... See more keywords
Implementation of a molecular tumor board at a regional level to improve access to targeted therapy
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DOI: 10.1007/s10147-020-01661-6
Abstract: Background With the development of precision oncology, Molecular Tumor Boards (MTB) are developing in many institutions. However, the implementation of MTB in routine clinical practice has still not been thoroughly studied. Material and methods Since… read more here.
Keywords: patients uga; molecular tumor; oncology; 2015 2016 ... See more keywords
Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy
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DOI: 10.1038/s41467-020-18613-3
Abstract: Next-generation sequencing (NGS) can identify novel cancer targets. However, interpreting the molecular findings and accessing drugs/clinical trials is challenging. Furthermore, many tumors show resistance to monotherapies. To implement a precision strategy, we initiated a multidisciplinary… read more here.
Keywords: strategy; tumor board; mtb; molecular tumor ... See more keywords
Abstract SY08-02: Reshaping cancer care delivery through multi-disciplinary molecular tumor boards
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DOI: 10.1158/1538-7445.am2018-sy08-02
Abstract: Rapidly growing access to next-generation DNA sequencing technology has put the promise of precision oncology in reach, which is to individualize cancer care by matching molecular abnormalities found in a patient9s tumor with specific treatments.… read more here.
Keywords: cancer care; molecular tumor; cancer; oncology ... See more keywords
Patient perspectives on molecular tumor profiling: “Why wouldn’t you?”
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DOI: 10.1186/s12885-019-5920-x
Abstract: AimThis study explored the attitudes of patients with advanced cancer towards MTP and return of results, prior to undergoing genomic testing within a research program.MethodsParticipants were recruited as part of the longitudinal PiGeOn (Psychosocial Issues… read more here.
Keywords: patient perspectives; molecular tumor; study; perspectives molecular ... See more keywords
Effects of molecular tumor board and different NGS panels implementation for the treatment of patients with cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e18511
Abstract: e18511Background: Molecular Tumor Boards (MTBs) for patient selection and assessment of treatment options were created for adequate precision medicine delivering. We evaluated the implementation of... read more here.
Keywords: board different; treatment; molecular tumor; tumor board ... See more keywords
Clinical utility of a molecular tumor board (MTB) in a community oncology practice.
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DOI: 10.1200/jco.2022.40.16_suppl.e15038
Abstract: e15038 Background: We convened a molecular tumor board in an oncology specialty practice of 60 oncologists. Monthly meetings were held remotely, with participation of molecular oncology experts from Caris Life Sciences. Cases were selected for… read more here.
Keywords: oncology; practice; tumor; molecular tumor ... See more keywords
Development and validation of ACTE-MTB: A tool to systematically assess the maturity of molecular tumor boards
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DOI: 10.1371/journal.pone.0268477
Abstract: Molecular tumor boards (MTBs) require specialized activities to leverage genomic data for therapeutic decision-making. Currently, there are no defined standards for implementing, executing, and tracking the impact of MTBs. This study describes the development and… read more here.
Keywords: tool; acte mtb; molecular tumor; maturity ... See more keywords
Supporting Molecular Tumor Boards in Molecular-Guided Decision-Making - The Current Status of Five German University Hospitals
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DOI: 10.3233/978-1-61499-759-7-48
Abstract: BACKGROUND German university hospitals have started to establish molecular tumor boards in order to enable physicians to make molecular-guided decisions. OBJECTIVE Our aim was to describe the organizational structure and procedures which are currently supporting… read more here.
Keywords: university hospitals; german university; molecular tumor; tumor boards ... See more keywords
Role of the Molecular Tumor Board for the Personalized Treatment of Patients with Metastatic Breast Cancer: A Focus on the State of the Art in Italy
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DOI: 10.3390/cancers15061727
Abstract: Simple Summary Molecular tumor boards (MTBs) aim to translate the results of genomic tests into clinical practice in order to set-up the most appropriate therapeutic strategy for the individual patient. Genomic tests represent a challenge… read more here.
Keywords: molecular tumor; breast cancer; metastatic breast; patients metastatic ... See more keywords
Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal
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DOI: 10.3390/diagnostics10020093
Abstract: Clinicians in molecular tumor boards (MTB) are confronted with a growing amount of genetic high-throughput sequencing data. Today, at German university hospitals, these data are usually handled in complex spreadsheets from which clinicians have to… read more here.
Keywords: analysis specification; requirements analysis; molecular tumor; specification molecular ... See more keywords