Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02603-2
Abstract: Lysine-selective molecular tweezers are promising drug candidates against proteinopathies, viral infection, and bacterial biofilm. Despite demonstration of their efficacy in multiple cellular and animal models, important questions regarding their mechanism of action, including cell penetrance… read more here.
Keywords: molecular tweezers; penetrant concentrate; tweezers cell; lysine selective ... See more keywords
Dual switchable molecular tweezers incorporating anisotropic MnIII-salphen complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt01465f
Abstract: An alternative strategy for the synthesis of terpyridine based switchable molecular tweezers has been developed to incorporate anisotropic Mn(iii)-salphen complexes. The free ligand was synthesized using a building block strategy based on Sonogashira coupling reactions… read more here.
Keywords: salphen; molecular tweezers; switchable molecular; two salphen ... See more keywords
Molecular tweezers - a new class of potent broad-spectrum antivirals against enveloped viruses.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06737k
Abstract: A new supramolecular approach to broad spectrum antivirals utilizes host guest chemistry between molecular tweezers and lysine/arginine as well as choline. Basic amino acids in amyloid-forming SEVI peptides (semen-derived enhancers of viral infection) are included… read more here.
Keywords: spectrum antivirals; molecular tweezers; new class; tweezers new ... See more keywords