Molecular Underpinnings Governing Genetic Complexity of ETS-Fusion-Negative Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.07.001
Abstract: Inter- and intra-patient molecular heterogeneity of primary and metastatic prostate cancer (PCa) confers variable clinical outcome and poses a formidable challenge in disease management. High-throughput integrative genomics and functional approaches have untangled the complexity involved… read more here.
Keywords: ets fusion; molecular underpinnings; fusion negative; prostate cancer ... See more keywords
Defining the molecular underpinnings controlling cardiomyocyte proliferation.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20211180
Abstract: Shortly after birth, mammalian cardiomyocytes (CM) exit the cell cycle and cease to proliferate. The inability of adult CM to replicate renders the heart particularly vulnerable to injury. Restoration of CM proliferation would be an… read more here.
Keywords: cell; proliferation; cell cycle; molecular underpinnings ... See more keywords
Molecular underpinnings of enzalutamide resistance.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine-related cancer"
DOI: 10.1530/erc-17-0136
Abstract: Prostate cancer (PCa) is among the most common adult malignancies, and the second leading cause of cancer-related death in men. As PCa is hormone-dependent, blockade of the androgen receptor (AR) signaling is an effective therapeutic… read more here.
Keywords: enzalutamide resistance; resistance; cancer; molecular underpinnings ... See more keywords