Molecularly Targeted Cancer Medications and Kidney Health
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.41221
Abstract: This cohort study evaluates the 2-year incidence and relative rates of progressive kidney dysfunction in patients treated with molecularly targeted cancer medications. read more here.
Keywords: kidney health; molecularly targeted; targeted cancer; cancer medications ... See more keywords
A Tumor Microenvironments‐Adapted Polypeptide Hydrogel/Nanogel Composite Boosts Antitumor Molecularly Targeted Inhibition and Immunoactivation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202200449
Abstract: Various macro/microscopic biomaterials have been developed for controlled drug delivery in the combination therapy of malignancies. However, uncertain loading ratio, release sequence, and spatiotemporal distribution of drugs hinder their synergistic therapeutic effects and clinical applications.… read more here.
Keywords: hydrogel; microenvironments adapted; molecularly targeted; tumor microenvironments ... See more keywords
Efficacy of molecularly targeted agents given in the randomised trial SHIVA01 according to the ESMO Scale for Clinical Actionability of molecular Targets.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2019.09.001
Abstract: BACKGROUND A randomised trial SHIVA01 compared the efficacy of matched molecularly targeted therapy outside their indications based on a prespecified treatment algorithm versus conventional chemotherapy in patients with metastatic solid tumours who had failed standard… read more here.
Keywords: trial shiva01; shiva01; randomised trial; scale clinical ... See more keywords
Neuro-ophthalmic side effects of molecularly targeted cancer drugs
Sign Up to like & getrecommendations! Published in 2018 at "Eye"
DOI: 10.1038/eye.2017.222
Abstract: The past two decades has been an amazing time in the advancement of cancer treatment. Molecularly targeted therapy is a concept in which specific cellular molecules (overexpressed, mutationally activated, or selectively expressed proteins) are manipulated… read more here.
Keywords: immune checkpoint; neuro ophthalmic; ophthalmic side; molecularly targeted ... See more keywords
Prognosis of patients with newly diagnosed glioblastoma treated with molecularly targeted drugs combined with radiotherapy vs temozolomide monotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017759
Abstract: Abstract Background: Glioblastoma (GB) is one of the most common malignancies with limited standard therapies such as surgery, radiotherapy (RT) plus temozolomide (TMZ). Molecularly targeted drugs have been investigated among various clinical trials and are… read more here.
Keywords: molecularly targeted; glioblastoma; patients newly; targeted drugs ... See more keywords
Abstract 839: The clinical C/EBPβ antagonist peptide lucicebtide synergizes with molecularly targeted therapies in GBM
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-839
Abstract: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor, with median overall survival (OS) following standard-of-care treatment of 15-18 months and 5-year survival of less than 10%. Despite extensive characterization of the genetic… read more here.
Keywords: molecularly targeted; lucicebtide synergizes; clinical ebp; gbm ... See more keywords
Phase I/II dose-finding design for molecularly targeted agent: Plateau determination using adaptive randomization
Sign Up to like & getrecommendations! Published in 2018 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280216631763
Abstract: Conventionally, phase I dose-finding trials aim to determine the maximum tolerated dose of a new drug under the assumption that both toxicity and efficacy monotonically increase with the dose. This paradigm, however, is not suitable… read more here.
Keywords: dose finding; efficacy; molecularly targeted; phase dose ... See more keywords
Gene fusions: A retrospective analysis of therapies and treatments of MTB patients over 7 years.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e15183
Abstract: e15183 Background: Gene fusions (GF) are less common than single nucleotide variants, amplifications, and deletions, but have been suggested to be more predictive of responses to specific molecularly targeted therapies than other types of molecular… read more here.
Keywords: analysis; molecularly targeted; targeted therapy; gene fusions ... See more keywords
Real-world adoption of adjuvant molecularly targeted therapy and immunotherapy for resected stage Ib-III non-small cell lung cancer within the Veterans Health Administration.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e20020
Abstract: e20020 Background: Emerging evidence supports the use of adjuvant systemic therapies for appropriately selected patients with early-stage, resected non-small cell lung cancer (NSCLC). The real-world adoption of these therapies is unknown, although prior studies have… read more here.
Keywords: therapy; real world; molecularly targeted; stage ... See more keywords
Development of New Molecularly Targeted Agents in Inflammatory Bowel Disease.
Sign Up to like & getrecommendations! Published in 2025 at "Internal medicine"
DOI: 10.2169/internalmedicine.5410-25
Abstract: Inflammatory bowel disease (IBD) is a multifactorial disorder resulting from a complex interplay among genetic predisposition, immune dysregulation, intestinal microbiota, and environmental factors. This dynamic interaction leads to aberrant immune activation within the gastrointestinal tract,… read more here.
Keywords: disease; molecularly targeted; bowel disease; development new ... See more keywords
Molecularly Targeted Small Molecule Inhibitor Therapy for Pediatric Acute Lymphoblastic Leukemia: A Comprehensive Review of Clinical Trials
Sign Up to like & getrecommendations! Published in 2025 at "Cancers"
DOI: 10.3390/cancers17203322
Abstract: Simple Summary Acute lymphoblastic leukemia (ALL) is the most frequent cancer of childhood. Although most children are cured with modern frontline chemoimmunotherapy regimens, those with high-risk genetics and/or relapsed/refractory diseases still face poor outcomes. There… read more here.
Keywords: comprehensive review; acute lymphoblastic; lymphoblastic leukemia; molecularly targeted ... See more keywords