A Tumor MicroenvironmentsâAdapted Polypeptide Hydrogel/Nanogel Composite Boosts Antitumor Molecularly Targeted Inhibition and Immunoactivation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202200449
Abstract: Various macro/microscopic biomaterials have been developed for controlled drug delivery in the combination therapy of malignancies. However, uncertain loading ratio, release sequence, and spatiotemporal distribution of drugs hinder their synergistic therapeutic effects and clinical applications.… read more here.
Keywords: hydrogel; microenvironments adapted; molecularly targeted; tumor microenvironments ... See more keywords
Efficacy of molecularly targeted agents given in the randomised trial SHIVA01 according to the ESMO Scale for Clinical Actionability of molecular Targets.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2019.09.001
Abstract: BACKGROUND A randomised trial SHIVA01 compared the efficacy of matched molecularly targeted therapy outside their indications based on a prespecified treatment algorithm versus conventional chemotherapy in patients with metastatic solid tumours who had failed standard… read more here.
Keywords: trial shiva01; shiva01; randomised trial; scale clinical ... See more keywords
Neuro-ophthalmic side effects of molecularly targeted cancer drugs
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DOI: 10.1038/eye.2017.222
Abstract: The past two decades has been an amazing time in the advancement of cancer treatment. Molecularly targeted therapy is a concept in which specific cellular molecules (overexpressed, mutationally activated, or selectively expressed proteins) are manipulated… read more here.
Keywords: immune checkpoint; neuro ophthalmic; ophthalmic side; molecularly targeted ... See more keywords
Prognosis of patients with newly diagnosed glioblastoma treated with molecularly targeted drugs combined with radiotherapy vs temozolomide monotherapy
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DOI: 10.1097/md.0000000000017759
Abstract: Abstract Background: Glioblastoma (GB) is one of the most common malignancies with limited standard therapies such as surgery, radiotherapy (RT) plus temozolomide (TMZ). Molecularly targeted drugs have been investigated among various clinical trials and are… read more here.
Keywords: molecularly targeted; glioblastoma; patients newly; targeted drugs ... See more keywords
Phase I/II dose-finding design for molecularly targeted agent: Plateau determination using adaptive randomization
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DOI: 10.1177/0962280216631763
Abstract: Conventionally, phase I dose-finding trials aim to determine the maximum tolerated dose of a new drug under the assumption that both toxicity and efficacy monotonically increase with the dose. This paradigm, however, is not suitable… read more here.
Keywords: dose finding; efficacy; molecularly targeted; phase dose ... See more keywords