In-Cell Single-Molecule Analysis of Molecular State and Reaction Kinetics Coupling.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-33-6064-8_3
Abstract: Cellular signaling is regulated by the spatiotemporal dynamics and kinetics of molecular behavior. To investigate the mechanisms at the molecular level, fluorescence single-molecule analysis is an effective method owing to the direct observation of individual… read more here.
Keywords: state; single molecule; analysis; cell ... See more keywords
Single-Molecule Analysis of SARS-CoV-2 Binding to C-Type Lectin Receptors
Sign Up to like & getrecommendations! Published in 2023 at "Nano Letters"
DOI: 10.1021/acs.nanolett.2c04931
Abstract: Despite intense scrutiny throughout the pandemic, development of efficacious drugs against SARS-CoV-2 spread remains hindered. Understanding the underlying mechanisms of viral infection is fundamental for developing novel treatments. While angiotensin converting enzyme 2 (ACE2) is… read more here.
Keywords: single molecule; molecule analysis; molecule; type ... See more keywords
Single-molecule analysis reveals multi-state folding of a guanine riboswitch.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2252
Abstract: Guanine-responsive riboswitches undergo ligand-dependent structural rearrangements to control gene expression by transcription termination. While the molecular basis for ligand recognition is well established, the associated structural rearrangements and the kinetics involved in the formation of… read more here.
Keywords: state; guanine; single molecule; molecule analysis ... See more keywords
Single-molecule analysis of actin filament debranching by cofilin and GMF
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115129119
Abstract: Significance Essential physiological processes such as cell migration and endocytosis require the assembly and catalyzed disassembly of the cytoskeletal branched networks composed of actin filaments and the Arp2/3 complex. We used single-molecule fluorescence microscopy to… read more here.
Keywords: gmf; single molecule; molecule analysis; actin ... See more keywords