LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "molecule binding" as a keyword



Deep Learning-Based Label-Free Surface-Enhanced Raman Scattering Screening and Recognition of Small-Molecule Binding Sites in Proteins.

Sign Up to like & get
recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c01158

Abstract: Identification of small-molecule binding sites in proteins is of great significance in analysis of protein function and drug design. Modified sites can be recognized via proteolytic cleavage followed by liquid chromatography-mass spectrometry (LC-MS); however, this… read more here.

Keywords: sites proteins; small molecule; deep learning; binding sites ... See more keywords

Explainable RNA-Small Molecule Binding Affinity Prediction Based on Multiview Enhancement Learning

Sign Up to like & get
recommendations! Published in 2025 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.5c01064

Abstract: RNA has the potential to serve as a drug target, requiring RNA-small molecule binding affinity to screen potential drugs generally. However, accurately predicting RNA-small molecule binding affinity remains a highly challenging task. This study proposes… read more here.

Keywords: rna small; binding affinity; molecule binding; small molecule ... See more keywords

Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide.

Sign Up to like & get
recommendations! Published in 2024 at "ACS chemical biology"

DOI: 10.1021/acschembio.4c00538

Abstract: We report the development of Tether-seq, a transcriptome-wide screen to probe RNA-small molecule interactions using disulfide tethering. This technique uses s4U metabolic labeling to provide sites for reversible and covalent attachment of small molecule disulfides… read more here.

Keywords: molecule; molecule binding; transcriptome wide; disulfide tethering ... See more keywords

Detecting and Directing Single Molecule Binding Events on H-Si(100) with Application to Ultradense Data Storage.

Sign Up to like & get
recommendations! Published in 2019 at "ACS nano"

DOI: 10.1021/acsnano.9b07637

Abstract: Many diverse material systems are being explored to enable smaller, more capable and energy efficient devices. These bottom up approaches for atomic and molecular electronics, quantum computation, and data storage all rely on a well-developed… read more here.

Keywords: molecule binding; data storage; single molecule; binding events ... See more keywords

Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel

Sign Up to like & get
recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09333-4

Abstract: G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Although studies have provided insight into these interactions, the mechanism of how these events are modulated by Gβγ and the… read more here.

Keywords: potassium; small molecule; toxin phosphatidylinositides; binding toxin ... See more keywords

MVRBind: multi-view learning for RNA-small molecule binding site prediction

Sign Up to like & get
recommendations! Published in 2025 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbaf489

Abstract: Abstract RNA plays a critical role in cellular processes, and its dysregulation is linked to many diseases, positioning RNA-targeted drugs as an important area of research. Accurate prediction of RNA-small molecule binding sites is crucial… read more here.

Keywords: rna small; molecule binding; binding sites; small molecule ... See more keywords

RNA language model and graph attention network for RNA and small molecule binding sites prediction

Sign Up to like & get
recommendations! Published in 2025 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btaf447

Abstract: Abstract Motivation The structural complexities enable RNA to serve as a versatile molecular scaffold capable of binding small molecules with high specificity. Understanding these interactions is essential for elucidating RNA’s role in disease mechanisms and… read more here.

Keywords: molecule binding; rna small; language; binding sites ... See more keywords

Augmented base pairing networks encode RNA-small molecule binding preferences

Sign Up to like & get
recommendations! Published in 2020 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaa583

Abstract: Abstract RNA-small molecule binding is a key regulatory mechanism which can stabilize 3D structures and activate molecular functions. The discovery of RNA-targeting compounds is thus a current topic of interest for novel therapies. Our work… read more here.

Keywords: base pairing; small molecule; molecule binding; rna small ... See more keywords

Advances in Methods for Accurate Prediction of RNA–Small Molecule Binding Sites: From Isolated to AI-Integrated Strategies

Sign Up to like & get
recommendations! Published in 2025 at "Pharmaceuticals"

DOI: 10.3390/ph18101593

Abstract: Predicting RNA–small molecule binding sites is essential for developing RNA-targeted drugs. Identifying these sites experimentally is often costly, making computational methods essential for drug discovery. While traditional approaches rely on limited information, recent AI advancements… read more here.

Keywords: rna small; molecule binding; prediction; binding sites ... See more keywords