Deep Learning-Based Label-Free Surface-Enhanced Raman Scattering Screening and Recognition of Small-Molecule Binding Sites in Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01158
Abstract: Identification of small-molecule binding sites in proteins is of great significance in analysis of protein function and drug design. Modified sites can be recognized via proteolytic cleavage followed by liquid chromatography-mass spectrometry (LC-MS); however, this… read more here.
Keywords: sites proteins; small molecule; deep learning; binding sites ... See more keywords
Detecting and Directing Single Molecule Binding Events on H-Si(100) with Application to Ultradense Data Storage.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b07637
Abstract: Many diverse material systems are being explored to enable smaller, more capable and energy efficient devices. These bottom up approaches for atomic and molecular electronics, quantum computation, and data storage all rely on a well-developed… read more here.
Keywords: molecule binding; data storage; single molecule; binding events ... See more keywords
Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09333-4
Abstract: G-protein-gated inward rectifying potassium channels (GIRKs) require Gβγ subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Although studies have provided insight into these interactions, the mechanism of how these events are modulated by Gβγ and the… read more here.
Keywords: potassium; small molecule; toxin phosphatidylinositides; binding toxin ... See more keywords
Augmented base pairing networks encode RNA-small molecule binding preferences
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa583
Abstract: Abstract RNA-small molecule binding is a key regulatory mechanism which can stabilize 3D structures and activate molecular functions. The discovery of RNA-targeting compounds is thus a current topic of interest for novel therapies. Our work… read more here.
Keywords: base pairing; small molecule; molecule binding; rna small ... See more keywords