New small‐molecule compound Hu‐17 inhibits estrogen biosynthesis by aromatase in human ovarian granulosa cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3492
Abstract: Estrogen‐dependent cancers (breast, endometrial, and ovarian) are among the leading causes of morbidity and mortality in women worldwide. Aromatase is the main enzyme that catalyzes the biosynthesis of estrogen, which drives proliferation, and antiestrogens can… read more here.
Keywords: molecule compound; small molecule; estrogen; aromatase ... See more keywords
Multistimuli-responsive small-molecule compound with aggregation-induced emission enhancement characteristics: preparation, properties and applications
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj04962a
Abstract: A novel multifunction luminescent small-molecule compound with hydrophilic chains was successfully designed and synthesized, which exhibited aggregation-induced emission enhancement (AIEE) characteristics. Even more interesting, it exhibited responsive behavior to temperature, pH and UV irradiation. In… read more here.
Keywords: small molecule; solution; luminescence intensity; molecule compound ... See more keywords
Small-Molecule Compound CY-158-11 Inhibits Staphylococcus aureus Biofilm Formation
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00045-23
Abstract: Most bacteria exist in the form of biofilms, often strongly adherent to various surfaces, causing bacterial resistance and chronic infections. In general, antibacterial drugs are not effective against biofilms. ABSTRACT Staphylococcus aureus is an important… read more here.
Keywords: small molecule; compound 158; biofilm formation; molecule compound ... See more keywords
Abstract 3205: A nanomolar potency small-molecule compound against castration-resistant and bone metastatic prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3205
Abstract: A standard treatment for prostate cancer (PCa) is androgen deprivation therapy (ADT) that suppresses androgen receptor (AR) signaling axis. Although initially responsive, most patients receiving ADT eventually develop metastatic castration-resistant prostate cancer (CRPC), with more… read more here.
Keywords: cancer; small molecule; prostate cancer; molecule compound ... See more keywords
Novel small-molecule compound VCP979 attenuates renal fibrosis in male rats with unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221147569
Abstract: Renal fibrosis is a hallmark of chronic kidney disease, while efficient therapy against renal fibrosis is still lacking. In this study, we investigated the role of a novel small-molecule compound VCP979 on renal fibrosis and… read more here.
Keywords: small molecule; renal fibrosis; molecule compound; novel small ... See more keywords
Small-molecule compound SYG-180-2-2 attenuates Staphylococcus aureus virulence by inhibiting hemolysin and staphyloxanthin production
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1008289
Abstract: Multi-drug resistant Staphylococcus aureus infection is still a serious threat to global health. Therefore, there is an urgent need to develop new antibacterial agents based on virulence factor therapy to overcome drug resistance. Previously, we… read more here.
Keywords: small molecule; staphylococcus aureus; molecule compound; virulence ... See more keywords
Small-Molecule Compound SYG-180-2-2 to Effectively Prevent the Biofilm Formation of Methicillin-Resistant Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.770657
Abstract: The resistance of methicillin-resistant Staphylococcus aureus (MRSA) has augmented due to the abuse of antibiotics, bringing about difficulties in the treatment of infection especially with the formation of biofilm. Thus, it is essential to develop… read more here.
Keywords: biofilm; molecule compound; small molecule; syg 180 ... See more keywords
Identification of a Small Molecule Compound Active against Antibiotic-Tolerant Staphylococcus aureus by Boosting ATP Synthesis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076242
Abstract: Antibiotic tolerance poses a threat to current antimicrobial armamentarium. Bacteria at a tolerant state survive in the presence of antibiotic treatment and account for persistence, relapse and recalcitrance of infections. Antibiotic treatment failure may occur… read more here.
Keywords: small molecule; tolerant; staphylococcus aureus; molecule compound ... See more keywords
A novel small molecule compound VCP979 improves ventricular remodeling in murine models of myocardial ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2019.4413
Abstract: Persistent ventricular remodeling following myocardial ischemia/reperfusion (MI/R) injury results in functional decompensation and eventual progression to heart failure. VCP979, a novel small-molecule compound developed in-house, possesses anti-inflammatory and anti-fibrotic activities. In the present study, no… read more here.
Keywords: molecule compound; small molecule; novel small; vcp979 ... See more keywords