Multiplexed Fluoro-electrochemical Single-Molecule Counting Enabled by SiC Semiconducting Nanofilm.
Sign Up to like & getrecommendations! Published in 2024 at "Nano letters"
DOI: 10.1021/acs.nanolett.4c03199
Abstract: A major challenge for ultrasensitive analysis is the high-efficiency determination of different target single molecules in parallel with high accuracy. Herein, we developed a quantitative fluoro-electrochemical imaging approach for direct multiplexed single-molecule counting with a… read more here.
Keywords: single molecule; molecule counting; nanofilm; fluoro electrochemical ... See more keywords
Highly Selective FRET-Aided Single-Molecule Counting of MicroRNAs Labeled by Splinted Ligation.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01526
Abstract: MicroRNAs (miRNAs) are short non-coding RNAs that play an important role in regulating gene expression. Since miRNAs are abnormally expressed in various cancers, they are considered to be promising biomarkers for early cancer diagnosis. However,… read more here.
Keywords: single molecule; molecule; molecule counting; aided single ... See more keywords
Quantitative Microscopic Observation of Base-Ligand Interactions via Hydrogen Bonds by Single-Molecule Counting.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c11260
Abstract: Chemical properties have been based on statistical averages since the introduction of Avogadro's number. The lack of suitable methods for counting identified single molecules has posed challenges to counting statistics. The selectivity, affinity, and mode… read more here.
Keywords: single molecule; hydrogen bonds; molecule; molecule counting ... See more keywords
Purely electrical SARS-CoV-2 sensing based on single-molecule counting
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr07787b
Abstract: The majority of RNA based COVID-19 diagnostics employ enzymatic amplification to achieve high sensitivity, but this relies on arbitrary thresholding, which complicates the comparison of test results and may lead to false outcomes. Here we… read more here.
Keywords: single molecule; purely electrical; electrical sars; molecule counting ... See more keywords
B-104 Detection of Blood-Based GFAP Using a Novel Single-Molecule Counting Technology
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Chemistry"
DOI: 10.1093/clinchem/hvaf086.502
Abstract: Glial fibrillary acidic protein (GFAP) is an intermediate filament protein specifically present in astrocytes in the central nervous system. Elevated levels of GFAP in the cerebrospinal fluid (CSF) and blood of patients have been reported… read more here.
Keywords: detection; molecule counting; gfap; blood ... See more keywords
Development of a Single Molecule Counting Assay to Differentiate Chromophobe Renal Cancer and Oncocytoma in Clinics
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133242
Abstract: Malignant chromophobe renal cancer (chRCC) and benign oncocytoma (RO) are two renal tumor types difficult to differentiate using histology and immunohistochemistry-based methods because of their similarity in appearance. We previously developed a transcriptomics-based classification pipeline… read more here.
Keywords: single molecule; renal cancer; molecule counting; histology ... See more keywords