Identification and selectivity profiling of small-molecule degraders via multi-omics approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.03.007
Abstract: The therapeutic modality of targeted protein degradation promises to overcome limitations of traditional pharmacology. Small-molecule degraders recruit disease-causing proteins to E3 ubiquitin ligases, prompting their ubiquitination and degradation by the proteasome. The discovery, mechanistic elucidation,… read more here.
Keywords: multi omics; molecule degraders; small molecule; selectivity profiling ... See more keywords
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abh1486
Abstract: Description Small-molecule degraders of SUMO1 induce its ubiquitination and degradation through binding of CAPRIN1 in tumor cells in vitro and in vivo. Degrading the undruggable Ubiquitination controls degradation of proteins and is an enticing therapeutic… read more here.
Keywords: molecule; degradation; molecule degraders; small molecule ... See more keywords