Biomarkers and Target-Specific Small-Molecule Drugs in Alzheimer’s Diagnostic and Therapeutic Research: From Amyloidosis to Tauopathy
Sign Up to like & getrecommendations! Published in 2024 at "Neurochemical Research"
DOI: 10.1007/s11064-024-04178-w
Abstract: Alzheimer’s disease (AD) is the most common type of human dementia and is responsible for over 60% of diagnosed dementia cases worldwide. Abnormal deposition of β-amyloid and the accumulation of neurofibrillary tangles have been recognised… read more here.
Keywords: diagnostic therapeutic; molecule drugs; small molecule; target specific ... See more keywords
Small molecule drugs for the treatment of pruritus in patients with atopic dermatitis.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173242
Abstract: Chronic pruritus is a cardinal symptom of the inflammatory skin disease atopic dermatitis (AD). Pathogenic mechanisms in the periphery, spinal cord and the brain have been implicated in AD-related pruritus. Therefore, both systemic and topical… read more here.
Keywords: related pruritus; molecule drugs; treatment; small molecule ... See more keywords
Effect of chemical composition and sulfated modification of alginate in the development of delivery systems based on electrostatic interactions for small molecule drugs
Sign Up to like & getrecommendations! Published in 2020 at "Materials Letters"
DOI: 10.1016/j.matlet.2019.127235
Abstract: Abstract The ionic complexation of different chemical compositions of alginate and its sulfated derivative with tetracycline hydrochloride (TCH), as a cationic drug model, was investigated. The complexes of TCH with mannuronate-enriched alginate entrapped the highest… read more here.
Keywords: alginate; molecule drugs; small molecule; delivery systems ... See more keywords
Impact of the Unstirred Water Layer on the Permeation of Small-Molecule Drugs
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c01629
Abstract: Over the last two decades, numerous molecular dynamics (MD) simulation-based investigations have attempted to predict the membrane permeability to small-molecule drugs as indicators of their bioavailability, a majority of which utilize the inhomogeneous solubility diffusion… read more here.
Keywords: molecule; unstirred water; permeation; water layer ... See more keywords
Strategies for targeting RNA with small molecule drugs
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2111414
Abstract: ABSTRACT Introduction Historically, therapeutic treatment of disease has been restricted to targeting proteins. Of the approximately 20,000 translated human proteins, approximately 1600 are associated with diseases. Strikingly, less than 15% of disease-associated proteins are predicted… read more here.
Keywords: small molecule; targeting rna; molecule; molecule drugs ... See more keywords
New progress of small-molecule drugs in the treatment of inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2024 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000003026
Abstract: prior biologics. The results showed that the filgotinib 200-mg read more here.
Keywords: new progress; drugs treatment; progress small; molecule drugs ... See more keywords
It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1011901
Abstract: A novel class of protein misfolding characterized by either the formation of non-native noncovalent lasso entanglements in the misfolded structure or loss of native entanglements has been predicted to exist and found circumstantial support through… read more here.
Keywords: molecule; entanglement; molecule drugs; small molecule ... See more keywords
Predicting patent challenges for small-molecule drugs: A cross-sectional study
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Medicine"
DOI: 10.1371/journal.pmed.1004540
Abstract: Background The high cost of prescription drugs in the United States is maintained by brand-name manufacturers’ competition-free period made possible in part through patent protection, which generic competitors must challenge to enter the market early.… read more here.
Keywords: market; patent challenges; patent; molecule drugs ... See more keywords
Small-Molecule Drugs Offer Comparable Health Benefits To Biologics At Lower Costs.
Sign Up to like & getrecommendations! Published in 2024 at "Health affairs"
DOI: 10.1377/hlthaff.2024.00363
Abstract: The Inflation Reduction Act of 2022 requires that Medicare negotiate a Maximum Fair Price for selected small-molecule drugs nine years after their Food and Drug Administration (FDA) approval and thirteen years postapproval for selected biologics.… read more here.
Keywords: qaly; molecule drugs; drugs offer; small molecule ... See more keywords
Systematically integrative analysis identifies diagnostic and prognostic candidates and small-molecule drugs for lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Cancer Research"
DOI: 10.21037/tcr-21-526
Abstract: Background Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer (LC). However, the early-stage diagnostic rate is still low, and the 5-year overall survival (OS) rate remains poor. The present study aimed… read more here.
Keywords: small molecule; analysis; molecule drugs; lung adenocarcinoma ... See more keywords
Small-molecule drugs development for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1019412
Abstract: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no effective therapeutic drugs currently. The complicated pathophysiology of AD is not well understood, although beta-amyloid (Aβ) cascade and hyperphosphorylated tau protein were regarded… read more here.
Keywords: small molecule; disease; development; alzheimer disease ... See more keywords