Small molecule drugs for the treatment of pruritus in patients with atopic dermatitis.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173242
Abstract: Chronic pruritus is a cardinal symptom of the inflammatory skin disease atopic dermatitis (AD). Pathogenic mechanisms in the periphery, spinal cord and the brain have been implicated in AD-related pruritus. Therefore, both systemic and topical… read more here.
Keywords: related pruritus; molecule drugs; treatment; small molecule ... See more keywords
Effect of chemical composition and sulfated modification of alginate in the development of delivery systems based on electrostatic interactions for small molecule drugs
Sign Up to like & getrecommendations! Published in 2020 at "Materials Letters"
DOI: 10.1016/j.matlet.2019.127235
Abstract: Abstract The ionic complexation of different chemical compositions of alginate and its sulfated derivative with tetracycline hydrochloride (TCH), as a cationic drug model, was investigated. The complexes of TCH with mannuronate-enriched alginate entrapped the highest… read more here.
Keywords: alginate; molecule drugs; small molecule; delivery systems ... See more keywords
Strategies for targeting RNA with small molecule drugs
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2111414
Abstract: ABSTRACT Introduction Historically, therapeutic treatment of disease has been restricted to targeting proteins. Of the approximately 20,000 translated human proteins, approximately 1600 are associated with diseases. Strikingly, less than 15% of disease-associated proteins are predicted… read more here.
Keywords: small molecule; targeting rna; molecule; molecule drugs ... See more keywords
Systematically integrative analysis identifies diagnostic and prognostic candidates and small-molecule drugs for lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Cancer Research"
DOI: 10.21037/tcr-21-526
Abstract: Background Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer (LC). However, the early-stage diagnostic rate is still low, and the 5-year overall survival (OS) rate remains poor. The present study aimed… read more here.
Keywords: small molecule; analysis; molecule drugs; lung adenocarcinoma ... See more keywords
Small-molecule drugs development for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1019412
Abstract: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no effective therapeutic drugs currently. The complicated pathophysiology of AD is not well understood, although beta-amyloid (Aβ) cascade and hyperphosphorylated tau protein were regarded… read more here.
Keywords: small molecule; disease; development; alzheimer disease ... See more keywords
New Small Molecule Drugs for Thrombocytopenia: Chemical, Pharmacological, and Therapeutic Use Considerations
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20123013
Abstract: This review provides details about three small molecules that were recently approved by the FDA for the treatment of thrombocytopenia. The new treatments include lusutrombopag, avatrombopag, and fostamatinib. The first two drugs are orally active… read more here.
Keywords: drugs thrombocytopenia; molecule drugs; small molecule; treatment ... See more keywords
Small Molecule Drugs That Inhibit Phagocytosis
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020757
Abstract: In our initial publication on the in vitro testing of more than 200 compounds, we demonstrated that small molecules can inhibit phagocytosis. We therefore theorized that a small molecule drug discovery-based approach to the treatment… read more here.
Keywords: small molecule; drugs inhibit; inhibit phagocytosis; phagocytosis ... See more keywords
Small Molecule Drugs in Inflammatory Bowel Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14070637
Abstract: Inflammatory bowel diseases (IBDs), mainly represented by Crohn’s disease (CD) and Ulcerative Colitis (UC), are chronic disorders with an unclear pathogenesis. This incurable and iterative intestinal mucosal inflammation requires the life-long use of anti-inflammatory drugs… read more here.
Keywords: bowel; drugs inflammatory; inflammatory bowel; molecule drugs ... See more keywords
Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13101657
Abstract: Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in… read more here.
Keywords: multi organs; molecule drugs; organs chips; small molecule ... See more keywords