A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24575-x
Abstract: Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs. Poor efficacy of… read more here.
Keywords: readthrough; translational readthrough; small molecule; induces translational ... See more keywords
Abstract 1805: Identification of a small molecule that induces targeted protein degradation of ADAR1
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1805
Abstract: Adenosine deaminase acting on RNA (ADAR) are a family of enzymes that catalyzes the posttranscriptional conversion of adenosine to inosine in double-stranded RNA (dsRNA). Recent evidence suggests that genetic deletion of ADAR1 render tumors cells… read more here.
Keywords: small molecule; targeted protein; molecule; protein degradation ... See more keywords