Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells
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DOI: 10.1038/s41598-020-64348-y
Abstract: The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly binds dsDNAs. cGAS synthesizes… read more here.
Keywords: human cgas; cgas; small molecule; cgamp ... See more keywords