Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64348-y
Abstract: The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly binds dsDNAs. cGAS synthesizes… read more here.
Keywords: human cgas; cgas; small molecule; cgamp ... See more keywords
Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2319492121
Abstract: Significance KRASG12C inhibitors have shown clinical responses in KRASG12C-mutant lung cancer, but much less so in colon cancers having the same mutation. In lung cancer, acquired resistance limits the clinical benefit patients experience. Here, we… read more here.
Keywords: kras mutant; molecule inhibition; mutant cancers; small molecule ... See more keywords
Abstract 4496: Small molecule inhibition of previously “undrubbable” transcription factors with AI-guided functional proteomics
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4496
Abstract: Transcription factors (TFs) are central regulators of gene expression and key drivers of diseases such as cancer, autoimmune disorders, neurological disease, and metabolic conditions. Despite their critical role, TFs have long been considered “undruggable” due… read more here.
Keywords: molecule; molecule inhibition; small molecule; transcription factors ... See more keywords