Advances and Challenges in Machine Learning for RNA-Small Molecule Interaction Modeling: Review.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.5c00973
Abstract: RNA plays a pivotal role in biological processes such as gene expression regulation and protein synthesis. Targeting RNA with small molecules offers a novel therapeutic strategy for various diseases by directly modulating these processes. However,… read more here.
Keywords: rna small; molecule interaction; small molecule; machine learning ... See more keywords
RNA-Small-Molecule Interaction: Challenging the "Undruggable" Tag.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c01354
Abstract: RNA targeting, specifically with small molecules, is a relatively new and rapidly emerging avenue with the promise to expand the target space in the drug discovery field. From being "disregarded" as an "undruggable" messenger molecule… read more here.
Keywords: interaction challenging; molecule; molecule interaction; rna small ... See more keywords
Three-Dimensional Model for Planar Assembly of Triangular Molecules: Effect of Substrate–Molecule Interaction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.6b12735
Abstract: A three-dimensional (3D) model is proposed to study the self-assembly of triangular molecules at the solid–liquid interface and the effects of the surface–molecule interaction on molecular ordering. In our model the molecules are subject to… read more here.
Keywords: three dimensional; molecule interaction; dimensional model; model ... See more keywords