Fine-Tuning Plasmon-Molecule Interactions in Gold-BODIPY Nanocomposites: The Role of Chemical Structure and Noncovalent Interactions.
Sign Up to like & getrecommendations! Published in 2020 at "ChemPlusChem"
DOI: 10.1002/cplu.202000545
Abstract: Strong coupling between localized surface plasmons and molecular absorptions leads to remarkable changes in the photophysical properties of dye-loaded metal nanoparticles. Here, we report supramolecular nanocomposites consisting of BODIPY, tryptophan, and gold nanoparticles, and investigate… read more here.
Keywords: fine tuning; plasmon molecule; singlet oxygen; interactions gold ... See more keywords
Affinities and Kinetics Detection of Protein-Small Molecule Interactions with a Monolayer MoS2 -Based Optical Imaging Platform.
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DOI: 10.1002/smll.202202622
Abstract: Quantifying the binding kinetics and affinities of protein-small molecule interactions is critical for biomarker validation, drug discovery, and deep understanding of various biological processes at the molecular-scale. Novel approaches are demanded as most common label-free… read more here.
Keywords: small molecule; binding kinetics; molecule; molecule interactions ... See more keywords
NMR characterization of RNA small molecule interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.05.015
Abstract: Exciting discoveries of naturally occurring ligand-sensing and disease-linked noncoding RNAs have promoted significant interests in understanding RNA-small molecule interactions. NMR spectroscopy is a powerful tool for characterizing intermolecular interactions. In this review, we describe protocols… read more here.
Keywords: small molecule; rna small; spectroscopy; molecule interactions ... See more keywords
Fluorescence-based investigations of RNA-small molecule interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.05.017
Abstract: Interrogating non-coding RNA structures and functions with small molecules is an area of rapidly increasing interest among biochemists and chemical biologists. However, many biochemical approaches to monitoring RNA structures are time-consuming and low-throughput, and thereby… read more here.
Keywords: molecule; fluorescence based; small molecule; rna small ... See more keywords
Protein-induced fluorescence enhancement for a simple and universal detection of protein/small molecule interactions
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DOI: 10.1039/c8ra08515c
Abstract: We herein describe a novel and efficient method for the detection of protein/small molecule (SM) interactions, which relies on the protein-induced fluorescence enhancement (PIFE). In this method, a duplex probe is designed to position Cy3… read more here.
Keywords: protein induced; small molecule; induced fluorescence; protein small ... See more keywords
The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc09948d
Abstract: Quantifying phospholipid bilayer-small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of… read more here.
Keywords: interactions using; solution state; phospholipid bilayer; small molecule ... See more keywords
In-Cell NMR: Analysis of Protein–Small Molecule Interactions, Metabolic Processes, and Protein Phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20020378
Abstract: Nuclear magnetic resonance (NMR) spectroscopy enables the non-invasive observation of biochemical processes, in living cells, at comparably high spectral and temporal resolution. Preferably, means of increasing the detection limit of this powerful analytical method need… read more here.
Keywords: cell nmr; small molecule; protein small; molecule interactions ... See more keywords
High-Yield Characterization of Single Molecule Interactions with DeepTipTM Atomic Force Microscopy Probes
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DOI: 10.3390/molecules28010226
Abstract: Single molecule interactions between biotin and streptavidin were characterized with functionalized DeepTipTM probes and used as a model system to develop a comprehensive methodology for the high-yield identification and analysis of single molecular events. The… read more here.
Keywords: single molecule; methodology; molecule; microscopy ... See more keywords