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   Articles with "molecule level" as a keyword



Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level

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recommendations! Published in 2017 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-017-2728-1

Abstract: G-protein-coupled receptors (GPCRs) can constitute complexes with non-GPCR integral membrane proteins, while such interaction has not been demonstrated at a single molecule level so far. We here investigated the potential interaction between the thyrotropin receptor… read more here.

Keywords: protein coupled; single molecule; molecule level; interaction ... See more keywords

Carboplatin as an alternative to Cisplatin in chemotherapies: New insights at single molecule level.

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recommendations! Published in 2018 at "Biophysical chemistry"

DOI: 10.1016/j.bpc.2018.07.004

Abstract: Here we report a new study performed at single molecule level on the interaction of the antineoplastic drug Carboplatin and the DNA molecule - the main target of the drug inside cells in cancer chemotherapies.… read more here.

Keywords: molecule; single molecule; cisplatin; molecule level ... See more keywords

Single Molecule Level and Label-Free Determination of Multibiomarkers with an Organic Field-Effect Transistor Platform in Early Cancer Diagnosis.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c00897

Abstract: The single molecule level determination with a transistor (SiMoT) platform has attracted considerable attention in the recognition of various ultralow abundance biomolecules, while complicated labeling and testing processes limit its further applications. Recently, organic field-effect… read more here.

Keywords: label free; single molecule; platform; transistor ... See more keywords

Visualization and Quantification of Sortase Activity at the Single-Molecule Level via Transpeptidation-Directed Intramolecular Förster Resonance Energy Transfer.

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recommendations! Published in 2018 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.8b03716

Abstract: The sortase-catalyzed coupling reaction is an efficient strategy to incorporate chemically defined modifications into proteins of interest. Despite its widespread applications in protein chemistry, the conventional bulk fluorescence measurement is not sufficient to characterize sortase… read more here.

Keywords: single molecule; molecule level; sortase; activity ... See more keywords
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Molecule-Level g-C3N4 Coordinated Transition Metals as a New Class of Electrocatalysts for Oxygen Electrode Reactions.

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recommendations! Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.6b13100

Abstract: Organometallic complexes with metal-nitrogen/carbon (M-N/C) coordination are the most important alternatives to precious metal catalysts for oxygen reduction and evolution reactions (ORR and OER) in energy conversion devices. Here, we designed and developed a range… read more here.

Keywords: transition metals; molecule level; oxygen electrode; coordinated transition ... See more keywords

Single-molecule fluorescence multiplexing by multi-parameter spectroscopic detection of nanostructured FRET labels

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recommendations! Published in 2024 at "Nature Nanotechnology"

DOI: 10.1038/s41565-024-01672-8

Abstract: Multiplexed, real-time fluorescence detection at the single-molecule level can reveal the stoichiometry, dynamics and interactions of multiple molecular species in mixtures and other complex samples. However, fluorescence-based sensing is typically limited to the detection of… read more here.

Keywords: detection; spectroscopic; molecule; molecule level ... See more keywords

Direct observation of the wrapping/unwrapping of ssDNA around/from a SWCNT at the single-molecule level: towards tuning the binding mode and strength.

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recommendations! Published in 2018 at "Nanoscale"

DOI: 10.1039/c8nr06150e

Abstract: Complexation of single-stranded DNA (ssDNA) with a chiral single-walled carbon nanotube (SWCNT) exhibits surprising efficacy in CNT dispersion and sorting, optical sensing, and nanoelectronic device design. Studying the wrapping/unwrapping mechanism is challenging because an in… read more here.

Keywords: single molecule; wrapping unwrapping; molecule level; ssdna ... See more keywords

In situ fluorescent profiling of living cell membrane proteins at a single-molecule level.

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recommendations! Published in 2019 at "Chemical communications"

DOI: 10.1039/c9cc00244h

Abstract: We propose a signal amplification method that enables visualization analysis of membrane proteins on living cells at a single-molecule level. Using the proposed method, we achieved imaging of PTK7 membrane proteins on HeLa cells and… read more here.

Keywords: molecule level; membrane; membrane proteins; single molecule ... See more keywords

Automatic DNA replication tract measurement to assess replication and repair dynamics at the single-molecule level

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recommendations! Published in 2022 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btac533

Abstract: Abstract Motivation DNA fibre assay has a potential application in genomic medicine, cancer and stem cell research at the single-molecule level. A major challenge for the clinical and research implementation of DNA fibre assays is… read more here.

Keywords: single molecule; dna; molecule level; fibre ... See more keywords

Probing the mechanism of nick searching by LIG1 at the single-molecule level

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae865

Abstract: Abstract DNA ligase 1 (LIG1) joins Okazaki fragments during the nuclear replication and completes DNA repair pathways by joining 3′-OH and 5′-PO4 ends of nick at the final step. Yet, the mechanism of how LIG1… read more here.

Keywords: molecule level; mechanism; dna binding; dna ... See more keywords

DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells

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recommendations! Published in 2024 at "Cell"

DOI: 10.1101/2024.03.09.584267

Abstract: Accurate measurement of mechanical forces in cells is key to understanding how cells sense and respond to mechanical stimuli, a central aspect of mechanobiology. However, accurately quantifying dynamic forces at the single-molecule level in living… read more here.

Keywords: molecule; force dynamics; molecule level; living cells ... See more keywords