Complexation with a cognate antibody fragment facilitates affinity measurements of fluorescein-linked small molecule ligands.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c02304
Abstract: The availability of reliable methods for the characterization of the binding of small molecule ligands to protein targets is crucially im-portant for Drug Discovery. We have adapted a method, routinely used for the characterization of… read more here.
Keywords: molecule; methodology; molecule ligands; small molecule ... See more keywords
Self-Transfecting Micellar RNA: Modulating Nanoparticle Cell Interactions via High Density Display of Small Molecule Ligands on Micelle Coronas.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00657
Abstract: The intracellular delivery of synthetic nucleic acids represents a major challenge in biotechnology and in biomedicine. Methods to deliver short, double-stranded RNA to living cells are of particular interest because of the potential to engage… read more here.
Keywords: display small; high density; molecule ligands; small molecule ... See more keywords
Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society Reviews"
DOI: 10.1039/d2cs00387b
Abstract: The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-proteasome system that recruits substrates such as the hypoxia inducible factor for ubiquitination and subsequent proteasomal degradation. The ubiquitin-proteasome pathway can… read more here.
Keywords: small molecule; molecule ligands; von hippel; protac degraders ... See more keywords
Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26040841
Abstract: G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in recent years as novel targets, with untapped potential for anticancer research. Their potential stems from the fact that G-quadruplexes occur in functionally-important regions… read more here.
Keywords: molecule ligands; recent developments; small molecule; developments small ... See more keywords