Small-Molecule Modulation of Protein Homeostasis.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00077
Abstract: Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics.… read more here.
Keywords: protein; molecule modulation; protein homeostasis; control ... See more keywords
Small-molecule modulation of p53 protein-protein interactions
Sign Up to like & getrecommendations! Published in 2019 at "Biological Chemistry"
DOI: 10.1515/hsz-2019-0405
Abstract: Abstract Small-molecule modulation of protein-protein interactions (PPIs) is a very promising but also challenging area in drug discovery. The tumor suppressor protein p53 is one of the most frequently altered proteins in human cancers, making… read more here.
Keywords: protein; protein interactions; molecule modulation; small molecule ... See more keywords