Sign Up to like & get
recommendations!
0
Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.006
Abstract: Design of small molecules that disrupt protein-protein interactions, including the interaction of RAS proteins and their effectors, may provide chemical probes and therapeutic agents. We describe here the synthesis and testing of potential small-molecule pan-RAS ligands,…
read more here.
Keywords:
ras proteins;
pan ras;
small molecule;
molecule pan ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.073
Abstract: SUMMARY Id helix-loop-helix (HLH) proteins (Id1–4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to inhibit differentiation,…
read more here.
Keywords:
ocular neovascularization;
pan antagonist;
small molecule;
molecule pan ... See more keywords