SAR-Guided Development of Small-Molecule SERCA2a Activators: Discovery of Potent Indoline, Benzofuran, and Benzodioxole Analogs for Cardiovascular Applications.
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DOI: 10.1021/acs.jmedchem.5c01192
Abstract: Heart failure (HF) remains a major public health burden, with current therapies focused primarily on symptom management. Impaired activity of the cardiac Ca2+ pump SERCA2a is a hallmark of HF and a promising therapeutic target,… read more here.
Keywords: indoline benzofuran; molecule serca2a; small molecule; serca2a ... See more keywords