Structure-Guided Reprogramming of a Hydroxylase To Halogenate Its Small Molecule Substrate.
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DOI: 10.1021/acs.biochem.6b01173
Abstract: Enzymatic installation of chlorine/bromine into unactivated carbon centers provides a versatile, selective, and environmentally friendly alternative to chemical halogenation. Iron(II) and 2-(oxo)-glutarate (FeII/2OG)-dependent halogenases are powerful biocatalysts that are capable of cleaving aliphatic C-H bonds… read more here.
Keywords: hydroxylase; small molecule; molecule substrate; structure ... See more keywords