COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2022.106201
Abstract: The coronavirus disease 2019 (COVID-19) pandemic had grounded the world to a standstill. As the disease continues to rage two years on, it is apparent that effective therapeutics are critical for a successful endemic living… read more here.
Keywords: covid promise; promise small; lessons learnt; small molecule ... See more keywords
Diverse targets of SMN2-directed splicing-modulating small molecule therapeutics for spinal muscular atrophy.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad259
Abstract: Designing an RNA-interacting molecule that displays high therapeutic efficacy while retaining specificity within a broad concentration range remains a challenging task. Risdiplam is an FDA-approved small molecule for the treatment of spinal muscular atrophy (SMA),… read more here.
Keywords: small molecule; spinal muscular; molecule; muscular atrophy ... See more keywords