High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
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DOI: 10.1016/j.ab.2018.01.025
Abstract: K-RAS is mutated in approximately 30% of human cancers, resulting in increased RAS signaling and tumor growth. Thus, RAS is a highly validated therapeutic target, especially in tumors of the pancreas, lung and colon. Although… read more here.
Keywords: nucleotide exchange; small molecules; ras signaling; molecules bind ... See more keywords