Proteoform-Specific Protein Binding of Small Molecules in Complex Matrices.
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DOI: 10.1021/acschembio.6b01018
Abstract: Characterizing the specific binding between protein targets and small molecules is critically important for drug discovery. Conventional assays require isolation and purification of small molecules from complex matrices through multistep chromatographic fractionation, which may alter… read more here.
Keywords: small molecules; proteoform specific; molecules complex; complex matrices ... See more keywords
New 19F NMR methodology reveals structures of molecules in complex mixtures of fluorinated compounds
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06057k
Abstract: Although the number of natural fluorinated compounds is very small, fluorinated pharmaceuticals and agrochemicals are numerous. 19F NMR spectroscopy has a great potential for the structure elucidation of fluorinated organic molecules, starting with their production… read more here.
Keywords: fluorinated compounds; methodology; complex mixtures; molecules complex ... See more keywords