Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins.
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DOI: 10.1021/acs.jmedchem.0c01500
Abstract: Macrocycles and cyclic peptides are increasingly attractive therapeutic modalities as they often have improved affinity, are able to bind to extended protein surfaces, and otherwise have favorable properties. Macrocyclization of a known binder may stabilize… read more here.
Keywords: molecules peptides; automated design; therapeutic applications; macrocycles therapeutic ... See more keywords
COVID-19 Docking Server: A meta server for docking small molecules, peptides and antibodies against potential targets of COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa645
Abstract: Abstract Motivation The coronavirus disease 2019 (COVID-19) caused by a new type of coronavirus has been emerging from China and led to thousands of death globally since December 2019. Despite many groups have engaged in… read more here.
Keywords: molecules peptides; covid docking; small molecules; docking server ... See more keywords