Small molecules that target group II introns are potent antifungal agents
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemical biology"
DOI: 10.1038/s41589-018-0142-0
Abstract: Specific RNA structures control numerous metabolic processes that impact human health, and yet efforts to target RNA structures de novo have been limited. In eukaryotes, the self-splicing group II intron is a mitochondrial RNA tertiary… read more here.
Keywords: target group; molecules target; small molecules; group ... See more keywords
How can we improve the design of small molecules to target thioredoxin reductase for treating cancer?
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2021.1854220
Abstract: The ubiquitous thioredoxin reductase (TrxR, encoded by TXNRD gene) enzymes are essential to maintain the cellular redox homeostasis. The most outstanding function of TrxR is to keep its native subs... read more here.
Keywords: thioredoxin reductase; improve design; reductase; design small ... See more keywords