Enzyme‐mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry
Sign Up to like & getrecommendations! Published in 2022 at "ChemCatChem"
DOI: 10.1002/cctc.202200140
Abstract: Molnupiravir (Lagevrio®) is an orally‐administered anti‐COVID‐19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient… read more here.
Keywords: molnupiravir paving; mediated synthesis; synthesis; enzyme mediated ... See more keywords
Embracing Uncertainties Over the Evidence of New Oral Antivirals for COVID‐19: Challenges in Pharmacoepidemiologic Research
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.2195
Abstract: Since the beginning of the COVID-19 pandemic, efforts have been made to develop new therapies for COVID19.1,2 The drugs developed in the meantime focus on completing a COVID-19 response strategy to prevent serious illness, hospitalization,… read more here.
Keywords: evidence new; uncertainties evidence; embracing uncertainties; evidence ... See more keywords
Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27730
Abstract: Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp) are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 (COVID‐19) pandemic and its future variants of severe acute respiratory syndrome coronavirus… read more here.
Keywords: severe acute; syndrome coronavirus; coronavirus; molnupiravir ... See more keywords
Review on molnupiravir as a promising oral drug for the treatment of COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02841-3
Abstract: During the COVID-19 pandemic, various drug candidates have been developed, molnupiravir (MK-4482 and EIDD-2801), which is a new orally anti-viral agent under development for the treatment of COVID-19, is under study in the final stage… read more here.
Keywords: chemistry; molnupiravir; treatment covid; drug ... See more keywords
Molnupiravir; molecular and functional descriptors of mitochondrial safety
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2022.116003
Abstract: Molnupiravir is an orally active nucleoside analog antiviral drug that recently was approved by the U.S. FDA for emergency treatment of adult patients infected with the SARS-CoV-2 (COVID-19) virus and at risk for severe progression.… read more here.
Keywords: molnupiravir molecular; molnupiravir; descriptors mitochondrial; functional descriptors ... See more keywords
Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c00772
Abstract: Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation… read more here.
Keywords: molnupiravir 4482; molnupiravir; synthesis molnupiravir; 4482 eidd ... See more keywords
A Nanopore Based Molnupiravir Sensor.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c00447
Abstract: Nucleoside analogues are reagents that resemble the structure of natural nucleosides and are widely applied in antiviral and anticancer therapy. Molnupiravir, a recently reported nucleoside analogue drug, has shown its inhibitory effect against SARS-CoV-2. Rapid… read more here.
Keywords: molnupiravir sensor; pharmacology; based molnupiravir; molnupiravir ... See more keywords
The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2153828
Abstract: ABSTRACT Introduction Molnupiravir (MOV) is a broad-spectrum oral antiviral agent approved for the treatment of COVID-19. The results from in vitro and in vivo studies suggested MOV activity against many RNA viruses such as influenza… read more here.
Keywords: discovery development; preclinical discovery; molnupiravir; treatment ... See more keywords
Preliminary Clinical Experience of Molnupiravir to Prevent Progression of COVID-19 in Kidney Transplant Recipients
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004306
Abstract: Background. Recently, different therapeutic lines have been tried in the initial stage of the disease of COVID-19, including remdesivir and molnupiravir. There is scarce evidence on the efficacy and safety of molnupiravir in kidney transplant… read more here.
Keywords: covid; transplant recipients; kidney transplant; molnupiravir ... See more keywords
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abl7430
Abstract: There is an urgent need for an effective, oral, direct-acting therapeutic to block transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent progression to severe coronavirus disease 2019 (COVID-19). In a phase 2a… read more here.
Keywords: rna clearance; molnupiravir; infectious virus; sars cov ... See more keywords
Cost of Goods Analysis Facilitates an Integrated Approach to Identifying Alternative Synthesis Methodologies for Lower Cost Manufacturing of the COVID-19 Antiviral Molnupiravir
Sign Up to like & getrecommendations! Published in 2022 at "Gates Open Research"
DOI: 10.12688/gatesopenres.13509.1
Abstract: Orally delivered drugs offer significant benefits in the fight against viral infections, and cost-effective production is critical to their impact on pandemic response in low- and middle-income countries. One example, molnupiravir, a COVID-19 therapy developed… read more here.
Keywords: cost goods; cost; synthesis; molnupiravir ... See more keywords