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   Articles with "molnupiravir" as a keyword



Enzyme‐mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry

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recommendations! Published in 2022 at "ChemCatChem"

DOI: 10.1002/cctc.202200140

Abstract: Molnupiravir (Lagevrio®) is an orally‐administered anti‐COVID‐19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient… read more here.

Keywords: molnupiravir paving; mediated synthesis; synthesis; enzyme mediated ... See more keywords

Embracing Uncertainties Over the Evidence of New Oral Antivirals for COVID‐19: Challenges in Pharmacoepidemiologic Research

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recommendations! Published in 2022 at "Journal of Clinical Pharmacology"

DOI: 10.1002/jcph.2195

Abstract: Since the beginning of the COVID-19 pandemic, efforts have been made to develop new therapies for COVID19.1,2 The drugs developed in the meantime focus on completing a COVID-19 response strategy to prevent serious illness, hospitalization,… read more here.

Keywords: evidence new; uncertainties evidence; embracing uncertainties; evidence ... See more keywords

Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.27730

Abstract: Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp) are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 (COVID‐19) pandemic and its future variants of severe acute respiratory syndrome coronavirus… read more here.

Keywords: severe acute; syndrome coronavirus; coronavirus; molnupiravir ... See more keywords

Review on molnupiravir as a promising oral drug for the treatment of COVID-19

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recommendations! Published in 2022 at "Medicinal Chemistry Research"

DOI: 10.1007/s00044-021-02841-3

Abstract: During the COVID-19 pandemic, various drug candidates have been developed, molnupiravir (MK-4482 and EIDD-2801), which is a new orally anti-viral agent under development for the treatment of COVID-19, is under study in the final stage… read more here.

Keywords: chemistry; molnupiravir; treatment covid; drug ... See more keywords

Molnupiravir; molecular and functional descriptors of mitochondrial safety

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recommendations! Published in 2022 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2022.116003

Abstract: Molnupiravir is an orally active nucleoside analog antiviral drug that recently was approved by the U.S. FDA for emergency treatment of adult patients infected with the SARS-CoV-2 (COVID-19) virus and at risk for severe progression.… read more here.

Keywords: molnupiravir molecular; molnupiravir; descriptors mitochondrial; functional descriptors ... See more keywords
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Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

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recommendations! Published in 2021 at "ACS Omega"

DOI: 10.1021/acsomega.1c00772

Abstract: Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation… read more here.

Keywords: molnupiravir 4482; molnupiravir; synthesis molnupiravir; 4482 eidd ... See more keywords

A Nanopore Based Molnupiravir Sensor.

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recommendations! Published in 2022 at "ACS sensors"

DOI: 10.1021/acssensors.2c00447

Abstract: Nucleoside analogues are reagents that resemble the structure of natural nucleosides and are widely applied in antiviral and anticancer therapy. Molnupiravir, a recently reported nucleoside analogue drug, has shown its inhibitory effect against SARS-CoV-2. Rapid… read more here.

Keywords: molnupiravir sensor; pharmacology; based molnupiravir; molnupiravir ... See more keywords

Surface engineering of carbon microspheres with nanoceria wrapped on MWCNTs: a dual electrocatalyst for simultaneous monitoring of molnupiravir and paracetamol

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recommendations! Published in 2024 at "RSC Advances"

DOI: 10.1039/d3ra08098f

Abstract: In the present study, nanoceria-decorated MWCNTs (CeNPs@MWCNTs) were synthesized using a simple and inexpensive process. Molnupiravir (MPV) has gained considerable attention in recent years due to the infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).… read more here.

Keywords: simultaneous monitoring; engineering carbon; molnupiravir; surface engineering ... See more keywords

The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)

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recommendations! Published in 2022 at "Expert Opinion on Drug Discovery"

DOI: 10.1080/17460441.2022.2153828

Abstract: ABSTRACT Introduction Molnupiravir (MOV) is a broad-spectrum oral antiviral agent approved for the treatment of COVID-19. The results from in vitro and in vivo studies suggested MOV activity against many RNA viruses such as influenza… read more here.

Keywords: discovery development; preclinical discovery; molnupiravir; treatment ... See more keywords

Real Clinical Effectiveness of Molnupiravir Against 30-day Mortality Among 74 541 SARS-CoV-2–Positive Patients: A Nationwide Cohort Study From the Czech Republic

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recommendations! Published in 2024 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofae685

Abstract: Abstract Background We examined the clinical effectiveness of molnupiravir in reducing deaths in a real-world cohort of adult patients with COVID-19 during the Omicron outbreak. Methods This was a population-wide retrospective cohort study in the… read more here.

Keywords: sars cov; molnupiravir; mortality; cohort study ... See more keywords

Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir

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recommendations! Published in 2024 at "Toxicological Sciences"

DOI: 10.1093/toxsci/kfae112

Abstract: Abstract Molnupiravir is registered or authorized in several countries as a 5-d oral coronavirus disease 2019 treatment for adults. Molnupiravir is a prodrug of the antiviral ribonucleoside β-D-N4-hydroxycytidine (NHC) that distributes into cells, where it… read more here.

Keywords: genotoxicity carcinogenicity; carcinogenicity study; molnupiravir; comprehensive genotoxicity ... See more keywords