The Interplay between Molten Globules and Heme Disassociation Defines Human Hemoglobin Disassembly.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.01.031
Abstract: Hemoglobin functions as a tetrameric oxygen transport protein, with each subunit containing a heme cofactor. Its denaturation, either in vivo or in vitro, involves autoxidation to methemoglobin, followed by cofactor loss and globin unfolding. We have proposed… read more here.
Keywords: heme disassociation; hemoglobin; molten globules; globules heme ... See more keywords
Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032424
Abstract: Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can… read more here.
Keywords: molten globules; dry molten; pre molten; wet dry ... See more keywords