Abstract 4205: Direct measurement of TA repeat expansions significantly outperforms MSI-H status as a predictor of sensitivity to the novel WRN inhibitor MOMA-341
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DOI: 10.1158/1538-7445.am2025-4205
Abstract: MOMA-341, first disclosed herein, is a novel, potent, and selective clinical stage small molecule inhibitor of the Werner RecQ like helicase (WRN) that acts through an allosteric, ATP-competitive binding mechanism and covalent ligation of WRN… read more here.
Keywords: repeat; moma 341; wrn; sensitivity ... See more keywords