MEK1‐dependent MondoA phosphorylation regulates glucose uptake in response to ketone bodies in colorectal cancer cells
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DOI: 10.1111/cas.15667
Abstract: The Mondo family transcription factor MondoA plays a pivotal role in sensing metabolites, such as glucose, glutamine, and lactic acid, to regulate glucose metabolism and cell proliferation. Ketone bodies are important signals for reducing glucose… read more here.
Keywords: mondoa; ketone bodies; glucose uptake; phosphorylation ... See more keywords
Abstract B51: Adaptation to oncogene-induced metabolic stress by MondoA (MLXIP) drives common acute lymphoblastic leukemia (cALL) malignancy
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DOI: 10.1158/1538-7445.pedca19-b51
Abstract: MondoA (also known as MLXIP, MAX-like protein X interacting protein) is a metabolic stress sensor and a proglycolytic transcription factor potentially involved in metabolic addiction features of leukemia and the Warburg effect. MondoA dimerizes with… read more here.
Keywords: mlxip; metabolic stress; mondoa; call ... See more keywords
MondoA drives muscle lipid accumulation and insulin resistance.
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DOI: 10.1172/jci.insight.129119
Abstract: Obesity-related insulin resistance is associated with intramyocellular lipid accumulation in skeletal muscle. We hypothesized that in contrast to current dogma, this linkage is related to an upstream mechanism that coordinately regulates both processes. We demonstrate… read more here.
Keywords: insulin; accumulation; muscle; insulin resistance ... See more keywords