Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0101-z
Abstract: G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that mediate a variety of cellular response which make them a target of choice for drug development in many indications. It is now well established that GPCRs can… read more here.
Keywords: energy transfer; monitoring ligand; biology; resonance energy ... See more keywords
Epithelial monitoring through ligand-receptor segregation ensures malignant cell elimination
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DOI: 10.1126/science.abl4213
Abstract: Animals have evolved mechanisms, such as cell competition, to remove dangerous or nonfunctional cells from a tissue. Tumor necrosis factor signaling can eliminate clonal malignancies from Drosophila imaginal epithelia, but why this pathway is activated… read more here.
Keywords: cell; ligand receptor; epithelial monitoring; ligand ... See more keywords