Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype
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DOI: 10.1007/s12264-021-00732-6
Abstract: Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used an adeno-associated virus serotype 9 (AAV9)-delivered CRISPR/Cas9 system to… read more here.
Keywords: phenotype; system; parkinsonian phenotype; monkey brain ... See more keywords
Methods for mechanical delivery of viral vectors into rhesus monkey brain
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DOI: 10.1016/j.jneumeth.2020.108730
Abstract: BACKGROUND Modern molecular tools make it possible to manipulate neural activity in a reversible and cell-type specific manner. For rhesus monkey research, molecular tools are generally introduced via viral vectors. New instruments designed specifically for… read more here.
Keywords: rhesus monkey; vector; viral vectors; delivery ... See more keywords