Current-Controlled Electrochemical Approach Toward Mono- and Trifluorinated Isoindolin-1-one Derivatives.
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DOI: 10.1021/acs.orglett.4c00109
Abstract: An electrochemical intramolecular 5-exo-dig aza-cyclization of 2-alkynylbenzamides and subsequent nucleophilic fluorination have been developed to afford the highly selective synthesis of mono- and trifluorinated isoindolin-1-one derivatives. This work demonstrates the unique capability of synthetic electrochemistry… read more here.
Keywords: controlled electrochemical; isoindolin one; current controlled; mono trifluorinated ... See more keywords